Christopher Cole

NÜRNBERG / GERMANY - APRIL 7, 2019: Siemens Logo on an office building in Nürnberg. Siemens is a German engineering company | Image Credit: © filmbildfabrik - stock.adobe.com

Siemens AG has completed its $5.1 billion acquisition of Boston-based Dotmatics, a provider of research and development software for the life sciences sector (1). The deal brings Dotmatics under the umbrella of Siemens’ Digital Industries Software division and marks a significant expansion of Siemens’ artificial intelligence (AI)-driven product lifecycle management (PLM) portfolio into the life sciences domain.

Originally announced in April 2025 (2), Siemens described the transaction as a “strategic milestone” that aligns with structural changes in healthcare—such as aging populations, broader access to medical care, and increasing demand for collaborative, data-integrated R&D environments (1). The acquisition is part of Siemens’ ONE Tech Company strategy, aimed at enhancing digital capabilities across high-growth industrial sectors.

·Siemens’ acquisition of Dotmatics enhances AI-driven drug development, connecting R&D to manufacturing through a unified digital thread.

·Dotmatics’ Scientific Intelligence Platform will streamline pharmaceutical workflows, accelerating discovery, development, and production cycles.

·Pharma manufacturers gain access to Siemens’ expanded digital twin and PLM tools, enabling scalable, data-integrated, and compliant operations.

“By acquiring Dotmatics, we’re strategically strengthening our position in Life Sciences and creating a world-leading AI-powered PLM software portfolio as part of Siemens Xcelerator,” said 

Roland Busch, president and CEO of Siemens

 AG (2). “Artificial intelligence has emerged as a transformative force across various industries, and its application in life sciences is becoming increasingly important.”

Connecting R&D to manufacturing in the pharma value chain

The Dotmatics platform centers around its Scientific Intelligence Platform, Luma, which supports AI-powered, multimodal drug development and data contextualization (1). The software facilitates seamless collaboration, connects previously siloed data across R&D and manufacturing, and creates a continuous digital thread through the pharmaceutical development lifecycle.

“With Dotmatics, we’re building a new era of innovation in Life Sciences,” said Busch. “From research through to production—we’re creating a unique, end-to-end digital thread: We combine Dotmatics’ scientific intelligence with our industrial AI technologies and digital twins. This will allow us to help our customers accelerate breakthroughs, reduce development cycles, and bring life-saving pharmaceuticals faster and more affordably to the market.”

For Siemens, the acquisition opens up an additional $11 billion in total addressable market within industrial software (1). Dotmatics is expected to generate more than $300 million in revenue in fiscal year 2025. Siemens projects medium-term revenue synergies of around $100 million annually, scaling up to more than $500 million in the longer term. The acquisition is expected to be immediately accretive to growth, profitability, and cash flow.

“The acquisition of Dotmatics drives strong revenue synergies and is highly profitable and cash generative,” said 

Ralf P. Thomas, chief financial officer of Siemens

 AG (2). “Financing will be provided primarily through the sale of shares in listed companies, including Siemens Healthineers.”

Siemens’ push into scientific innovation

The transaction also reflects the evolution of Dotmatics itself. Formerly known as Insightful Science, the company rebranded as Dotmatics in April 2022 following its acquisition of Protein Metrics and a period of expansion under the ownership of Insight Partners (2). 

, emphasized the strategic alignment in the press release announcing the deal.

“Following an exciting journey with Insight Partners, where Dotmatics achieved remarkable growth and portfolio expansion, we are thrilled to announce our new chapter with Siemens,” said Swalla (2). “Combining our next-generation scientific intelligence platform and industry-leading scientific applications together with Siemens' digital twin and AI capabilities, we’ll drive a new wave of innovation in life sciences R&D.”

Latest in high-profile software acquisitions

The Dotmatics acquisition follows closely on the heels of Siemens’ $10 billion acquisition of Altair Engineering, completed in April (3). That deal brought new simulation, high-performance computing, and AI capabilities into Siemens’ industrial software offerings and was similarly integrated into the Siemens Xcelerator platform.

“We welcome the Altair community of customers, partners and colleagues to Siemens,” Busch said at the time of that acquisition (3). “Adding Altair’s groundbreaking innovations to the Siemens Xcelerator platform will create the world's most complete AI-powered design, engineering and simulation portfolio.”

Together, these back-to-back deals underscore Siemens’ aggressive push into domains in which digital twin technology, data integration, and AI are reshaping complex product development. With Dotmatics and Altair, Siemens now commands an expanded portfolio capable of supporting highly regulated industries like pharmaceuticals with the digital tools needed to meet rising demand, tighter timelines, and greater product complexity.

Siemens Completes Acquisition of Dotmatics

Siemens Acquires Dotmatics, Extending AI Software Portfolio into Life Sciences

Siemens Acquires Altair to Create Most Complete AI-powered Portfolio of Industrial Software

Articles

Siemens expands AI-driven pharma software portfolio, integrating Dotmatics’ platform to connect drug research, development, and manufacturing digitally.

Siemens Finalizes $5.1B Dotmatics Acquisition

mainz,Rhineland-Palatinate /germany - 16 07 2022: the biontech company building and flags in mainz germany | Image Credit: © Tobias Arhelger - stock.adobe.com

In a move to reportedly consolidate and expand its capabilities in messenger RNA (mRNA)-based medicine, BioNTech has announced plans to acquire CureVac through an all-stock transaction valued at approximately $1.25 billion (1). The acquisition aims to accelerate the development and manufacturing of next-generation mRNA immunotherapies for oncology and infectious diseases by combining the strengths of the two German-based biotechnology companies.

Strategic fit to strengthen BioNTech’s oncology pipeline

This acquisition forms a cornerstone of BioNTech’s long-term oncology strategy. The company intends to integrate CureVac’s proprietary mRNA platforms and advanced research infrastructure, particularly its R&D and manufacturing facilities in Tübingen, Germany, to complement existing efforts across BioNTech’s immunotherapy programs (1).

·BioNTech's acquisition of CureVac strengthens mRNA cancer immunotherapy R&D and supports its next milestone in oncology strategy execution.

·The deal enhances BioNTech’s proprietary mRNA design, delivery, and manufacturing technologies for advanced therapeutic development.

·CureVac's integration expands BioNTech’s mRNA platform, optimizing formulation and production for future oncology pipeline growth.

“This transaction is another building block in BioNTech’s oncology strategy and an investment in the future of cancer medicine,” said 

, CEO and co-founder of BioNTech (1). “We intend to bring together complementary capabilities and leverage technologies with the goal of advancing the development of innovative and transformative cancer treatments and establishing new standards of care for various types of cancer in the coming years.”

CureVac’s scientific expertise and its progress in mRNA design and lipid nanoparticle delivery systems are expected to support BioNTech’s pan-tumor immunotherapy candidates, including its lead PD-L1xVEGF-A bispecific antibody, 

“To me, this transaction is more than a business decision, it represents a shared commitment to leverage the full potential of mRNA as a disruptive technology to develop transformative therapies with greater scale and speed,” said 

, MD, CEO of CureVac (1). “For more than two decades, both companies have operated with related ambitions, often tackling challenges from different angles. This transaction aims at combining complementary scientific capabilities, proprietary technologies, and manufacturing expertise in the mRNA field under one roof.”

Expanding the mRNA platform in oncology and infectious disease

BioNTech’s acquisition of CureVac reflects a broader ambition to dominate the mRNA therapeutic landscape beyond COVID-19 (1). While BioNTech is best known for co-developing the first approved mRNA vaccine with Pfizer, the company continues to invest heavily in mRNA research targeting various solid tumors and infectious diseases.

CureVac adds to this effort with an R&D pipeline that includes off-the-shelf and personalized mRNA cancer vaccines, and prophylactic vaccine candidates (1). Its technology platforms are built to enhance immunogenicity while maintaining low-dose efficiency—a key factor for scalability and safety. By combining assets, both companies aim to streamline mRNA drug development pipelines and manufacturing workflows, potentially reducing timelines for delivering clinical-stage therapies to patients. The integrated platform will be positioned to support mRNA applications from discovery to commercialization.

The deal, approved unanimously by the boards of both companies, is expected to close in 2025, pending customary regulatory clearances and a minimum 80% share acceptance rate from CureVac shareholders—although BioNTech retains the option to reduce this threshold to 75% (1).

This news comes just 10 days after BioNTech announced a global co-development and co-commercialization agreement valued at up to $11.1 billion for 

 (2). Under that deal, BMS will provide BioNTech with an upfront payment of $1.5 billion and an additional $2 billion in non-contingent anniversary payments through 2028. 

 is also eligible to receive up to $7.6 billion in development, regulatory, and commercial milestones.

BioNTech Announces Strategic Transaction to Acquire CureVac in Public Exchange Offer

BioNTech to Receive Up to $11.1 Billion in Deal with BMS to Develop Immuno-Oncology Agent.

The acquisition boosts BioNTech’s mRNA design and manufacturing capabilities, accelerating development of next-gen cancer immunotherapies.

CureVac to Be Acquired by BioNTech in $1.25B Deal to Advance mRNA Cancer Therapies

Neurons, Active nerve cells, Conceptual illustration of neuronal cells with bright connecting nodes in the abstract dark space, illustration in high resolution, 3D rendering | Image Credit: © Eric - stock.adobe.com

, has raised €11.25 million (US$12.9 million) in an oversubscribed seed round to advance a novel therapeutic approach targeting treatment-resistant depression (1). The financing round was co-led by 

, and the French Tech Seed Fund managed by 

, on behalf of the French government, under the 

 initiative. Additional participants included 

The company is developing a first-in-class neuroplastogen based on pioneering academic research that aims to restore neuroplasticity without the drawbacks of current treatments like psychedelics or ketamine derivatives (1). This effort targets the intracellular protein Elk1, a central modulator of brain circuits involved in reward and emotional regulation. The approach stems directly from translational work conducted at the 

Linking Neuroscience to Therapeutic Development

·European biotech startup Elkedonia secures €11.25M (US$12.9M) in seed funding, integrating Sorbonne University research with Argobio’s drug development expertise.

·Novel Elk1-targeting antidepressants aim to restore neuroplasticity without sedation or hallucinations, addressing treatment-resistant depression.

·Elkedonia develops first-in-class, non-addictive neuroplastogens that avoid synaptic targets, offering a safer alternative to ketamine-based therapies.

Elkedonia was founded by Argobio, a biotech venture studio focused on translational science, and is built on research led by 

, director of research at CNRS. Her studies have identified Elk1 as a key regulatory protein in brain plasticity, disruptions of which are implicated in depression, PTSD, addiction, and anhedonia (2).

“Trauma, chronic stress, substance abuse and other factors can contribute to major depressive disorders and anhedonia (the inability to experience pleasure), driven by an impaired neuroplasticity,” the company stated (1). “This disruption in the brain’s ability to adapt leads to a breakdown in its normal functioning.”

Elkedonia’s therapeutic platform seeks to inhibit Elk1, restoring neural adaptability without inducing hallucinations, sedation, or dependence. The company points to encouraging findings from preclinical and early clinical research, suggesting that targeting Elk1 may offer rapid antidepressant effects, in contrast to the delayed onset of conventional treatments.

Proceeds from the seed financing will support the optimization of small-molecule Elk1 inhibitors and the development of companion biomarkers (1). These efforts are central to Elkedonia’s strategy to deliver precision medicine in mental health, matching therapies to patient subtypes and tracking treatment response with objective measures.

“I am thrilled to welcome our founding seed investors and thank my colleagues at Argobio for their support in creating Elkedonia,” said 

, CEO and co-founder of Elkedonia (1). “The novelty of our neuroplastogen approach offers a strong value proposition supported by groundbreaking neuroscience research. We are positioned to make a significant impact on the treatment of major depressive disorders, bringing relief to all patients, including young people, adolescents and the elderly. In addition, our development of biomarkers will allow us to pursue a precision medicine for patient selection and treatment efficacy monitoring.”

The company’s focus on treatment-resistant depression addresses a growing and underserved population. Globally, major depressive disorder affects approximately 280 million people, with many patients failing to respond to existing therapies (3). This public health burden is particularly severe among adolescents and young adults, where depression-related suicide is a leading cause of death.

“Major depressive disorder is a large market of 300 million people globally that remains poorly addressed, with roughly one third of patients resistant to currently available treatments,” said 

, chairman of the management board of Argobio and managing partner at Kurma Partners. “Elkedonia serves as a first proof-of-concept for Argobio where we are extremely proud to have identified this opportunity to benefit human health and to have provided industry competencies to accelerate and de-risk product development.”

, investment director at WE Life Sciences, said, “Investing in Elkedonia demonstrates WE Life Sciences' commitment to advancing the best cutting-edge innovations through collaboration with top-tier European life sciences investors. We are proud to support the realization of this promising innovation from Argobio, while fostering its growth in Wallonia, Belgium, a region increasingly recognized for its excellence in health and biotechnology.”

“Bpifrance, as a founding investor of Argobio, is delighted to support the seed round of this promising new venture,” said 

, investment director Life Sciences at Bpifrance. “We are thrilled to develop the foundational research that comes from CNRS at Sorbonne University. This investment underscores our commitment to advancing mental health solutions, which is currently a priority for France.”

Elkedonia Closes EUR 11 Million Seed Round to Advance Neuroplastogens as Novel Therapeutics for Depression and Neuropsychiatric Disorders

Elkedonia will develop first-in-class Elk1 inhibitors for treatment-resistant depression, targeting neuroplasticity without psychedelic side effects.

Elkedonia Raises €11.25M Seed Round to Advance Neuroplastogen Therapy for Depression

Washington, DC, USA - June 24, 2022: The symbol of the U.S. Department of Health and Human Services is seen at the entrance to its headquarters in the Hubert H. Humphrey Building in Washington, DC | Image Credit: © Tada Images - stock.adobe.com.

On June 9, 2025, Secretary of Health and Human Services Robert F. Kennedy Jr. announced the dismissal of all 17 members of the Advisory Committee on Immunization Practices (ACIP), a Centers of Disease Control and Prevention (CDC)-affiliated body responsible for guiding vaccine policy in the United States (1). The decision was communicated through a Department of Health and Human Services (HHS) press release. While the Secretary holds the legal authority to appoint and remove committee members, the wholesale dismissal of the panel is an unprecedented step and has prompted concern across public health, scientific, and biopharmaceutical sectors. The news follows 

 of a restructuring to include the reduction of HHS workforce by 10,000 full-time employees.

·ACIP overhaul disrupts vaccine approval timelines, posing risks to clinical trial planning, FDA readiness, and seasonal launch strategies.

·Regulatory uncertainty from ACIP shake-up may delay vaccine reimbursement and market access, impacting commercial rollout and payer engagement.

·ACIP restructuring threatens US alignment with global vaccine policy, potentially undermining international regulatory harmonization and partnerships.

ACIP plays a foundational role in shaping immunization policy in the US. It provides evidence-based recommendations on the use of vaccines for children and adults, informs decisions about insurance coverage, and helps determine eligibility for publicly funded programs such as Vaccines for Children (VFC). In justifying the dismissals, Secretary Kennedy argued that a "clean sweep" was needed to "reestablish public confidence in vaccine science," asserting that future members would prioritize “public health and evidence-based medicine,” and avoid serving as a “rubber stamp for industry profit-taking agendas” (1).

Medical and scientific groups have pushed back against this characterization. The American Medical Association (AMA) stated that the decision “undermines trust and upends a transparent process that has saved countless lives,” while the Infectious Diseases Society of America called Kennedy’s accusations of bias “completely unfounded” (2,3). ACIP members are required to publicly disclose potential conflicts of interest and recuse themselves from votes where applicable. A government report previously cited by Kennedy to support his claims of systemic conflicts found no such widespread issues (4).

Industry groups have also raised serious concerns. The Biotechnology Innovation Organization (BIO), which represents biotechnology firms, including vaccine developers and manufacturers, criticized both the process and the timing of the dismissals (5). BIO President and CEO 

 emphasized that ACIP plays a legally mandated role not only in ensuring scientific rigor but also in determining how the US population accesses immunizations. Crowley noted that the removal of the committee members less than three weeks before ACIP’s next scheduled meeting risks derailing ongoing deliberations on critical vaccines, including those for respiratory syncytial virus (RSV), influenza, and human papillomavirus.

In particular, BIO highlighted that ACIP’s reviews involve months of preparation, including technical assessments by specialized working groups, and that a sudden overhaul disrupts this process. Crowley warned that such disruption could impair the committee’s ability to deliver timely, well-informed guidance—potentially putting public health at risk.

Impact on vaccine development and manufacturing

For vaccine developers and manufacturers of, the overhaul introduces short- and long-term uncertainty in the regulatory landscape. ACIP recommendations significantly influence vaccine uptake by guiding clinical practice, shaping insurance coverage decisions, and signaling public health priorities. An abrupt change in committee composition may delay decisions on new vaccines or introduce new criteria for evaluating safety and efficacy. This could directly affect investment planning, clinical trial design, and launch timelines, particularly for candidates in late-stage development or approaching FDA review.

Market access strategies are also likely to be affected. Reimbursement pathways for newly recommended vaccines depend in part on ACIP endorsement. Delays or inconsistencies in the committee’s operations could hinder payer engagement and commercial rollout, especially for seasonal or time-sensitive products. Manufacturers currently preparing for launches of RSV or updated influenza vaccines in the upcoming cycle may need to adjust expectations depending on how quickly the new committee is formed and operational.

Beyond immediate regulatory impacts, the restructuring raises broader strategic questions for vaccine research and development in the US. The longstanding credibility of ACIP has supported productive collaboration between government, academia, and industry, while also helping to align US policy with global regulatory norms. A perceived politicization of ACIP’s role or a reduction in scientific transparency may strain public–private partnerships and deter investment in vaccine-preventable disease areas.

In addition, international regulatory bodies often look to ACIP as a model for evidence-based immunization policy. If future decisions by the reconstituted committee are seen as politically motivated or inconsistent with global standards, this could affect regulatory harmonization and market access strategies for multinational firms.

The removal of all voting members of the ACIP introduces a period of heightened uncertainty for the pharmaceutical industry, particularly for vaccine developers, manufacturers, and regulatory affairs professionals. While the long-term implications will depend on who is appointed to the committee and how it operates going forward, the abruptness and scale of the change have disrupted a long-standing scientific and policy framework. Continued attention will be required to assess how future ACIP deliberations evolve and what this means for US immunization policy and pharmaceutical innovation.



Department of Health and Human Services. 

HHS Takes Bold Step to Restore Public Trust in Vaccines by Reconstituting ACIP

AMA Statement on Advisory Committee on Immunization Practices

Statement on the Advisory Committee on Immunization Practices. Press Release

RFK Jr. Boots All Members of the CDC’s Vaccine Advisory Committee

BIO Statement on HHS Dismissal of CDC Advisory Committee Members

The dismissal of all 17 members of the Advisory Committee on Immunization Practices has far-reaching impacts for the industry and beyond.

Implications of RFK Jr.’s CDC Vaccine Committee Overhaul for the Pharmaceutical Industry

 (pharma&) has received a regulatory variation from the UK’s 

Medicines and Healthcare products Regulatory Agency

 (MHRA), authorizing its wholly owned subsidiary, 

 GmbH, as an approved manufacturing site for the API in Pegasys (peginterferon alfa-2a), according to a May 28, 2025 news release from the company (1). This regulatory update marks a significant milestone in stabilizing the long-term supply chain of Pegasys in the United Kingdom and enables the company to begin product replenishment across the region.

Following the MHRA decision, pharma& expects that eligible patients in the UK will begin to see improved access to Pegasys in the coming weeks.

“We are delighted that the MHRA has granted approval for the production of Pegasys API at Loba biotech GmbH. This marks a critical step forward, building on the recent EMA [European Medicines Agency] approval, securing the path forward for Pegasys replenishment across the United Kingdom,” said E

, founder and managing director of pharma& (1).

·MHRA approval of Loba Biotech enables in-house Pegasys API production, reinforcing pharma&'s control over its biologics manufacturing process.

·UK Pegasys supply chain gains long-term stability as pharma& scales bio-manufacturing capacity at its Loba Biotech facility.

·pharma&’s investment in Pegasys API production reflects growing industry focus on supply chain resilience for essential biologic therapies.

Strategic Manufacturing Investment Supports Global Pegasys Continuity

The decision to invest in internal API manufacturing capabilities followed pharma&'s acquisition of Pegasys from F. Hoffmann-La Roche AG in 2021 (2). Roche had announced in 2019 that it would cease global commercialization of the product (1). Since then, pharma& has prioritized uninterrupted patient access to Pegasys, with a particular focus on markets affected by supply shortfalls.

Following the acquisition, pharma& observed a surge in demand for Pegasys, leading the company to invest in bio-manufacturing infrastructure at Loba biotech GmbH. The regulatory approval for this site underscores the company's commitment to securing reliable access to critical therapies.

“Since acquiring Pegasys, pharma& has remained dedicated to maintaining continuous access to this medicine for eligible patients,” Zagler added (1). “The MHRA’s approval, along with our investment in Loba biotech, represents pharma&’s ongoing commitment to preserving the availability of essential medicines and foster their development worldwide to leave no patient behind.”

While supply restoration in the UK and Europe is advancing, pharma& also continues to work closely with regulatory bodies in other regions, including the United States, to support expanded access for eligible patients.

Pegasys mechanism of action and indications

Pegasys is a pegylated type I interferon (IFN), primarily interferon alfa-2a, according to the release (1). Type I interferons—including IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω—are a class of alpha-helical cytokines central to innate and adaptive immune responses, with evolutionary origins tracing back approximately 500 million years. These proteins exert antiviral effects by binding to the interferon-α receptor (IFNAR), composed of IFNAR1 and IFNAR2 subunits.

Pegylation of interferon alfa-2a involves the covalent attachment of a branched polyethylene glycol (PEG) molecule, resulting in the formulation known as Pegasys (1). The 40-kilodalton PEG moiety enhances pharmacokinetics by acting as a protective barrier and extending systemic exposure.

In the UK, Pegasys has been authorized for the treatment of chronic hepatitis B (CHB) in adults and children aged three years and older, as well as chronic hepatitis C (CHC) in adults and children aged five years and older (1). CHC treatment in pediatric patients is approved in combination with ribavirin.

Full safety information and the Summary of Product Characteristics for Pegasys are accessible through the 

pharma& Receives MHRA Approval for Pegasys Manufacturing Site Variation, Adding Loba biotech for API Production and Ensuring a Reliable, Long-term Supply in the UK

Medicines & Healthcare products Regulatory Agency. 

MHRA approves Loba Biotech to manufacture Pegasys API, enabling pharma& to strengthen UK supply and ensure continued access for eligible patients.

pharma& Secures MHRA Approval for Pegasys API Production at Loba Biotech

 announced via a news release dated May 21, 2025, that it has signed an agreement to acquire 

., a clinical-stage biotechnology company specializing in therapies for neurodegenerative diseases (1). The acquisition aligns with Sanofi’s strategic emphasis on neurology and is intended to enhance its capabilities in early-stage drug development within this therapeutic area.

Vigil’s lead candidate, VG-3927, is an oral small molecule that acts as a TREM2 agonist. This compound is being prepared for a Phase II clinical trial in Alzheimer’s disease, according to the release (1). TREM2 activation is hypothesized to enhance the neuroprotective functions of microglia by promoting their migration to sites of neural injury, increasing their phagocytic activity, and supporting cell survival and proliferation. These functions are considered critical in mitigating chronic inflammation and debris accumulation in neurodegenerative conditions.

·Sanofi acquires clinical-stage biotech Vigil Neuroscience to expand its neurology drug pipeline focused on neurodegenerative disease therapies.

·VG-3927, Vigil's lead candidate, is a TREM2 agonist targeting microglial function; Sanofi plans to advance it into Phase II trials for Alzheimer’s.

·The deal reflects Sanofi’s strategic use of early investments to secure biotech assets and accelerate central nervous system drug development and manufacturing.

“This acquisition is fully supporting Sanofi’s strategic focus on neurology and on advancing science and leveraging our expertise in immunology to solve areas of critical unmet need,” said 

, head of research and development at Sanofi (1). TREM2 represents a compelling target at the intersection of immune dysregulation and neurodegeneration, particularly in people living with Alzheimer’s because they face devastating cognitive decline with limited treatment options. Vigil’s expertise is complementary to our capabilities in neurology and reinforces our dedication to developing innovative medicines to improve people’s lives. Vigil’s team are a welcome addition, and we look forward to working with them and the patient community.”

The news release notes that Vigil’s research is focused on the role of microglia in central nervous system disorders (1). In neurodegenerative diseases, microglial dysfunction contributes to progressive neuronal damage. Current Alzheimer’s treatments offer limited efficacy and stringent eligibility, underscoring the need for novel therapeutic approaches.

Sanofi’s acquisition follows a strategic $40 million investment made in June 2024, which included the exclusive right of first negotiation for VG-3927 (2). The decision to proceed with the full acquisition reflects Sanofi’s broader strategy of early equity investments to secure potential assets in critical areas of unmet medical need (1).

“We are incredibly proud of the extraordinary and diverse team at Vigil and the progress we have made in developing innovative TREM2-based therapeutics. We look forward to joining forces with Sanofi's team to leverage Sanofi’s resources, broad platform and far-reaching network to fully unlock and accelerate the development of VG-3927 for the potential treatment of Alzheimer’s disease—a devastating disease with significant unmet need,” said 

, president and chief executive officer of Vigil.

, Vigil’s second investigational molecule. The deal is expected to close in the third quarter of 2025 and will not impact Sanofi’s financial guidance for the year.

Sanofi to Acquire Vigil Neuroscience, Inc., Adding a New Investigational Medicine to Treat Alzheimer’s Disease to the Neurology Pipeline

Vigil Neuroscience Announces $40 Million Strategic Investment from Sanofi

Sanofi is acquiring Vigil Neuroscience, a biotech firm focused on novel neurodegenerative disease therapies, to boost its early-stage neurology pipeline.