Articles

Carrier-based formulations for dry powder inhalers are carefully designed to transport extremely small particles into the lungs. Jet milling can be used to micronize these particles, with both high and low shear mixing processes used to formulate mixtures capable of carrying the fine API particles into the deep lung. This paper looks at the requirements for pulmonary delivery via carrier-based inhaled powder formulations, and how jet milling can be used to manufacture effective and stable materials for these formulations


Diving Deep into Carrier-Based Formulation and Process Optimization

Analyzation of a diverse set of PROTAC (Proteolysis Targeting Chimeras –
a class of TPDs) structures and their calculated properties, identifying key structure-property trends that contribute to low oral bioavailability.

Molecular Properties of PROTACs and the Relationship to Formulation Design

Meeta B. Kratz (Global Vice President, Product Management & Marketing, Lonza Capsule and Health Ingredients) talks about Lonza's future and how that works in tandem to meet client needs.

Lonza's Commitment to the Future (Dec 2024) 

A case study in converting a solution formulation of a protein into an oral solid dosage form utilizing a fluid bed granulation process and some of the complexities involved.

Development Process for Transforming a Liquid Protein Solution into a Solid Oral Dosage Form

The packaging and distribution of clinical supplies is a fundamental piece to the
overall success of a clinical trial, and advance preparation can help establish a more
efficient supply chain. Selecting the best geographical location for those activities,
however, depends on the clinical trial protocol, business decisions, and even the
investigational medicinal product (IMP) being studied.


Clinical Supply Planning in Europe - Balancing Cost, Flexibility and Time

Drive growth by establishing integrated, AI-fueled lab systems and a data-driven corporate culture that’s ready and resilient, no matter what business challenges emerge tomorrow. Evolving to a Lab of the Future takes the right technologies, systems, and expert guidance.

Inside the Lab of the Future

Lucy Zhou, Skin Lab Manager, discusses the importance and applications for utilizing in vitro Release Testing during development of generic topical drug compounds.  Lucy discusses how IVRT can play a critical role by saving cost and time during product development and the techniques and applications for using in vitro testing to achieve desired product outcomes.  

A Discussion: In Vitro Release Testing and Its Application and Use in Generic Topical

Localized treatment approaches for diabetic neuropathic pain management, like pregabalin liposomal topical formulations, offer a novel strategy by directly targeting affected areas. Liposomes enhance skin permeability and sustain drug release, delivering pregabalin efficiently to peripheral nerves while reducing systemic exposure. In a proof-of-concept study using an IVPT and a diabetic neuropathic pain rat model, improved skin penetration and significant reductions in mechanical allodynia and thermal hyperalgesia were shown.  

Preparation and Characterization of Pregabalin Loaded Liposomes for Topical Drug Delivery:  Utilizing the Novel Platform Technology for the Effective Treatment of Neuropathic Pain Management

Lucy Zhou, Skin Lab Manager, discusses the importance and applications for utilizing IVPT during formulation development of novel topical compounds to help select excipients and permeation enhancers that will properly deliver the drug into the desired layer of the skin or system.

IVPT and Topical Drug Development: A Discussion on the Application and Importance of Using In-Vitro Permeation Testing as a Tool in Topical Drug Development

Semi-solid dosage forms are complex drug delivery systems containing one or more active ingredients dissolved or dispersed uniformly in the product. Viscosity modifiers are polymers that hydrate upon interaction with solvents and impart an increase in viscosity. It is often difficult to choose the right grade of the polymer and identify the correct amount that produces a consistent viscosity. The video presentation and research poster discuss the importance of polymer selection during formulation development. 

All Whitepapers