Contract Pharmaceuticals Limited (CPL)

Articles

Lucy Zhou, Skin Lab Manager, discusses the importance and applications for utilizing in vitro Release Testing during development of generic topical drug compounds.  Lucy discusses how IVRT can play a critical role by saving cost and time during product development and the techniques and applications for using in vitro testing to achieve desired product outcomes.  

A Discussion: In Vitro Release Testing and Its Application and Use in Generic Topical

Localized treatment approaches for diabetic neuropathic pain management, like pregabalin liposomal topical formulations, offer a novel strategy by directly targeting affected areas. Liposomes enhance skin permeability and sustain drug release, delivering pregabalin efficiently to peripheral nerves while reducing systemic exposure. In a proof-of-concept study using an IVPT and a diabetic neuropathic pain rat model, improved skin penetration and significant reductions in mechanical allodynia and thermal hyperalgesia were shown.  

Preparation and Characterization of Pregabalin Loaded Liposomes for Topical Drug Delivery:  Utilizing the Novel Platform Technology for the Effective Treatment of Neuropathic Pain Management

Lucy Zhou, Skin Lab Manager, discusses the importance and applications for utilizing IVPT during formulation development of novel topical compounds to help select excipients and permeation enhancers that will properly deliver the drug into the desired layer of the skin or system.

IVPT and Topical Drug Development: A Discussion on the Application and Importance of Using In-Vitro Permeation Testing as a Tool in Topical Drug Development

Semi-solid dosage forms are complex drug delivery systems containing one or more active ingredients dissolved or dispersed uniformly in the product. Viscosity modifiers are polymers that hydrate upon interaction with solvents and impart an increase in viscosity. It is often difficult to choose the right grade of the polymer and identify the correct amount that produces a consistent viscosity. The video presentation and research poster discuss the importance of polymer selection during formulation development. 