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A Technical Review of Twin Screw Extrusion Technologies for Life Science Applications

from A technical review of compounding, devolatilization, reactive processing, foaming and direct extrusion via twin screw extruders

Continuous twin screw extrusion system for soft gel casing replaces batch mixing operations

Soft gel capsules are dosage forms that have an oblong and smooth casing that encapsulates a liquid. The soft gel casing (or gel-mass) is formulated by mixing together gelatin (or alternative material) with water, plasticizer and other ingredients. Historically, soft gel casings have been prepared in a batch mixing operation that takes many hours to complete.