Thermo Fisher

Articles

Consistent quantification using qPCR and dPCR technology is essential for obtaining accurate and precise viral vector titers. 

Quantifying AAV Viral Titers: An Examination of qPCR and dPCR Technology Across Applications

The successful transition of drug products between developers
and manufacturers is equal parts science and art, defined by enabling processes, a culture of collaboration to support them, and, perhaps most important, a foundation of trust.



Technology transfers: Best practices for optimizing success and mitigating risk

Risky Assumptions for Addressing Limited Bioavailability 


To Err Is Human, to Correctly Formulate Is Divine

Whether it’s for scaling-up, moving to another facility, or moving to another outsourcing partner, technology transfers are part of the normal course of business. Learn about the 9 dos and don’ts of executing a successful technology transfer.


9 dos and don'ts of executing a successful technology transfer

Small molecule drug development has changed substantially
in recent years. With the heightened focus on molecularly
targeted therapies, small molecule active pharmaceutical
ingredients (APIs) and drug products are more complex
and potent than ever, requiring increasingly specialized
manufacturing processes and drug delivery solutions. At
the same time, the competitive demand for rapid entry into
clinical development—combined with accelerated review
pathways—translate into compressed manufacturing and
delivery timelines.


Expediting early-phase development of small molecules: An integrated approach

Outsourcing projects to CDMOs is becoming increasingly prevalent as drug
sponsors look to optimize their supply chain or conserve internal resources
for other projects. In 2021 alone, 46% of newly developed drugs were
outsourced. Drug sponsors can reap a variety of benefits by outsourcing
late-phase projects, but it comes with risks. The technology transfer that
must occur to transition a late-phase project to a CDMO is complex and
costly. The average cost of a tech transfer is around $1M, so partnering
with the wrong CDMO can be a costly mistake.
