Thermo Fisher Scientific

Articles

Read about the process utilized and results gained from the use of a two-phase scale-up strategy to manufacture three complex dry powder medium (DPM) formulations. The success of these projects relied on consistently producing acceptable prototype and cGMP material within the customer’s specifications and manufacturing timelines.

Successful manufacturing of dry powder media from development to large-scale cGMP production: A two-phase strategy (May 2024)

The importance of successfully scaling up cell culture media cannot be overstated. Not starting the process soon enough can introduce issues with solubility, manufacturability, procurement, and cost management. This article considers technical and commercial best practices that drug developers may enact so that they, their suppliers and media manufacturers, and in turn, their cell culture media remain on the most efficient path to market.

Accelerating cell culture media manufacturing from rapid prototyping through cGMP (May 2024)

When evaluating a potential vendor, whether for a catalog medium or custom formulation manufacturing, it is important to ensure it can meet your unique needs. This article details five top considerations to carefully evaluate when selecting a cell culture media supplier. Learn how to maximize confidence in your media supply, optimize productivity and help achieve long-term efficiency. 

What to look for in a cell culture media supplier: key considerations to reduce risks and manage costs

In this project, Thermo Fisher Scientific worked with a multinational biopharmaceutical company to investigate trace element variability in its custom cell culture media. Within a year, using a risk-based, collaborative approach, both teams were able to thoroughly characterize incoming specific raw materials and implement proactive measures for reducing the risk of impurities, ultimately providing the company with a long-term risk mitigation strategy.	

A collaborative study for understanding trace element variability in custom cell culture media (May 2024)

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This case study summarizes the outcomes of several media optimization projects and how the results helped manufacturers to achieve their desired scale-up goals, including enhancing productivity, maintaining product quality, and potentially improving return on investment (ROI).