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November 02, 2012
The promise of antibody drug conjugates is creating a network of partners among large pharma companies and specialized players.
October 02, 2012
Recent research on elucidating the structure and sequence of proteins involves examining the effect of microgravity on protein crystallization and a computational model for protein elucidation.
The authors examine the use of various grades of direct-compression mannitol in direct-compression tableting process to evaluate the content uniformity of micronized APIs and excipients in a solid-dosage formulation.
Particle-engineering technologies, such as crystal design for crystallization and producting cocrystals, particle-size reduction, and amorphous solid dispersions, help to optimize delivery of a drug.
September 02, 2012
Solubilizers play an important role in dissolving poorly soluble molecules. As the number of poorly soluble lipophilic and/or hydrophobic molecules increases-whether as "brick dusts" or waxy substances-the industry is struggling to identify the appropriate lipophilic excipients (surfactants, solubilizers, solvents or polymers) that can be used to develop such poorly soluble formulations into solid dosages and other forms of pharmaceutical products.
Industry and academia advance novel approaches for achieving enanioselectivity.
USP optimizes identification tests and impurities procedures.
September 01, 2012
A Q&A with BASF moderated by Patricia Van Arnum.
The authors explain chemical transformations that are achievable through certain biocatalytic routes.
August 02, 2012
Approaches to scaling up API syntheses center on ways to optimize process conditions and operability.
