Drug Development

Arvind K. Bansal is an associate professor at the National Institute of Pharmaceutical Education and Research, Sector-67, Phase-X, S.A.S. Nagar, Punjab 160062, India, tel 191 0 172 2214682 87, fax 191 0 172 2214692.

Articles

The authors examine the development and performance of coprocessed excipients, including testing them for flowability, compressibility, amd dilution potential.

Coprocessed Excipients for Solid Dosage Forms

Harpinder Kaur is a postgraduate student at the National Institute of Pharmaceutical Education and Research (NIPER).

The influence of light on the rate of moisture gain was investigated in 36 drug substances and 18 excipients.

Behavior of Uptake of Moisture by Drugs and Excipients

Ian Sellick is marketing director at Pall Corporation.

One of the greatest challenges facing biopharmaceutical manufacturers has been the primary recovery of recombinant materials from transgenic sources. As an alternative to existing methods, vibrating membrane technology, which is widely used in food and beverage processing, recently has been adapted to biopharmaceutical applications involving transgenic biosolutions.

Improving Protein Capture for Transgenic Drug Processing

Business Manager, pharmaceuticals and cosmetics, for Cerestar Food and Pharma Specialities Europe

Senior Specialist, pharmaceutical and cosmetics, for Cerestar Food and Pharma Specialities Europe

Erythritol is a bulk sweetener polyol that is suitable for a variety of reduced-calorie and sugar-free foods. It has been part of the human diet for thousands of years because of its presence in foods such as fruit, mushrooms and fermentation-derived products including wine, soy sauce and cheese. This article investigates the properties of erythritol and describes how it can be used as a pharmaceutical excipient.

Erythritol: A New Multipurpose Excipient

Pharmaceutical science & technology news.

September 2003

Saranjit Singh is a professor and head of the department of pharmaceutical analysis at the National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160062, India, tel. 91 172 214682, fax 91 172 214692.

The authors investigated the moisture gain of products containing ethambutol that were packaged in strip and blister packs as well as unpackaged formulations.

Behavior of Uptake of Moisture by Drugs and Excipients under Accelerated Conditions of Temperature and Humidity in the Absence and the Presence of Light

Shireesh P. Apte, PhD, is a lead scientist at Baxter I.V. Systems Inc.

As parenteral drug delivery becomes more complex and sophisticated, excipients that can facilitate drug (or gene) delivery to specific therapeutic targets will be required. An overwhelming majority of these excipients are derived from natural sources.

A Review of Classification of Emerging Excipients in Parenteral Medications

The tabletting properties of a new coprocessed excipient for direct compression were compared with a physical mixture of its components (separately and with drugs) and the individual constituents. The compaction properties were also investigated. Results indicated that the new excipient has excellent flow properties and demonstrates enhanced compressibility.

A Corn Starch/a-Lactose Monohydrate Compound as a Directly Compressible Excipient

Medicines and excipients are inseparable, with few exceptions - one cannot exist without the other. The Pharmaceutical Quality Group and other international bodies have developed good manufacturing practice (GMP) standards and guidelines to facilitate the effective supply of excipients. This article discusses the definition and significance of excipients, and highlights the importance of implementing the correct excipient manufacturing controls and standards.

PS 9100:2002 Pharmaceutical Excipients - An Updated GMP Standard for Excipients Suppliers

George Shlieout is the technical managing director at Magnesia GmbH, Postfach 2168, D-21311 Lüneburg, Germany, tel. +49 4131 871 018, fax +49 4131 871 055.

The aim of this work was to investigate the compactibility, compressibility and drug release behaviour of different fractions of a commercially available ethyl cellulose.

APIs and Excipients