Drug Development

Articles

Dalton Pharma Services completed an expansion in sterile filling and API manufacturing at its cGMP facility in Toronto, Canada.

Dalton Expands Canadian Manufacturing Facility

CDMO Alcami adds HPAPI capacity and cryogenic capabilities to its Wisconsin facility.

Alcami Expands US API Capacity

Irvine Scientific’s new product range includes chemically-defined, serum-free media, to increase productivity of viral vectors and recombinant proteins in suspension cultures.

Irvine Scientific Launches BalanCD HEK293 System for Large-Scale Expression of Proteins and Viral Vectors

Agilent Technologies announces plans to build a new oligo manufacturing facility in Colorado that will double current capacity.

Agilent Plans Expansion of Oligo Manufacturing Capacity

Jacobs Engineering Group was awarded a contract to provide engineering services and procurement for Alnylam Pharmaceuticals’ new manufacturing facility in Norton, Massachusetts.

Alnylam Moves Forward on Multi-Product RNAi Facility

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Recent research of efficient chiral synthesis technologies reveals potential uses in API manufacturing.

Chiral Advances Demonstrate Promise for API Synthesis

Enzymatic catalysis offers pharma manufacturers a way to implement the Principles of Green Chemistry.

Going Green with Biocatalysis

This paper describes a unique Prep-rP-HPLC technique that uses a C-18/C-8 derivatized silica coated with a hydrophobic quaternary ammonium salt or quaternary phosphonium salt that acts as an additional/surrogate stationary phase (AsP/ssP).

Purification of Peptides Using Surrogate Stationary Phases on Reversed-Phase Columns

Multiple methods are required for detecting and removing protein impurities.

Protein Impurities Pose Challenges

Randi Hernandez was science editor at Pharmaceutical Technology from September 2014 to May 2017.

The therapeutic candidate AZD8601is an investigational mRNA-based therapy that will be tested for its ability to regulate the protein that influences vascular tissue growth.

APIs and Excipients