APIs and Excipients

Safety by Design—Mitigating the Risk of Medication Errors Through Product Design

April 15, 2014

Experts share insights on how product appearance such as size, shape, color, and imprint can make a difference in reducing medication errors.

Controlled-Release Technologies Create Opportunities for Solid-Dosage Drug Formulators

April 15, 2014

Lifecycle management opportunities are impacting the development of controlled-release technologies for solid-dosage drugs.

A Practical Guide to Hot-Melt Extrusion Scale-Up for Pharmaceutical Applications

April 15, 2014

The author discusses various aspects of the hot-melt extrusion process and outlines a practical approach to scale-up.

Advances in Hot-Melt Extrusion Manufacturing

April 15, 2014

Charlie Martin, Leistritz Extrusion, describes hot-melt extrusion manufacturing processes and advances.

Obtaining User-Defined Particle Size Distribution Using Dry Granulation

April 15, 2014

The author examines the effect of compaction force, gap width, and sieve setup on granule size.

A Quality-by-Design Approach to Optimize In-Process Curing of EUDRAGIT NM 30 D

April 15, 2014

A study investigated the influence and correlation of critical process parameters for the optimization of in-process curing.

Selection of Excipients in Generic Formulations

April 15, 2014

The selection of excipients is important in generic formulations due to the impact it has on the risk and performance of generic drugs.

Appropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs

April 02, 2014

Increasing potency and growing interest in antibody-drug conjugates are creating challenges for manufacturers of HPAPIs.

Synthetic Biology: The Next Frontier in Chiral Chemistry for API Synthesis

March 02, 2014

The commercial availability of an increasing diversity of enzymes has led to the growing use of biocatalysts for API synthesis.

Demand Increases for Novel Excipients, but Manufacturers Still Face Challenges

February 28, 2014

PTSM: Pharmaceutical Technology Sourcing and Management

Drug formulators are looking for new excipients to address solubility and bioavailability issues and extend patent protection, but there are hurdles to using novel, specialized ingredients.