Drug Development

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Articles

Industry experts share their views on the outsourcing model and the current and future direction of contract chemical API manufacturing.

Gaining Insights on Contract Chemical API Manufacturing An Industry Roundtable

Commercial-scale amide formation and an improved process route for a tetracycline derivative are some recent developments in API synthesis.

Advancing API Synthesis

Industry experts share perspectives on risk assessment and mitigation in excipient manufacture and the excipient supply chain.

Risk Assessment of Excipients

A simple, rapid analytical method for the determination of palladium in pharmaceutical production samples will speed up development and optimization of reactions involving palladium catalysts.

Merck/PITT Collaboration Demonstrates Rapid Method for Evaluation of Residual Palladium

Stapled peptides offer promise to enable cell permeability, binding to therapeutic targets, and modulation of biological pathways.

Advancing Peptide Synthesis Through Stapled Peptides

Adeline Siew is editor for Pharmaceutical Technology Europe. She is also science editor for Pharmaceutical Technology.

Industry groups offered perspectives on the strengths and weaknesses of the European Falsified Medicines Directive.

Implications for APIs in the European Falsified Medicines Directive

External manufacturing plays a crucial role in pharmaceutical companies’ supply strategy. The author examines market trends for the captive and merchant global market for active pharmaceutical ingredients and intermediates.

A Shifting Landscape for the Global API Market

Novel, atom-efficient routes to amides from esters and carboxylic acids for more sustainable manufacturing.

Reducing the Complexity of Commercial-Scale Amide Formation

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

New routes enable the efficient synthesis of enantiopure sulfinamides and structurally and sterically diverse P-chiral phosphine oxides.

New Chiral Sulfur and Phosphorous Chemistry from Boehringer Ingelheim

Cocrystals can enable the formulation of solid dosage drugs, but the FDA's final guidelines have left concerns about how their use could impact development timelines, the drug product manufacturing process, and the intellectual property position of products containing cocrystals.

APIs and Excipients