Analytics

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Articles

NMR analysis provides crucial structural information of synthesized glycans while LC-MS/MS is ideal for quantitation of free sugars in biological matrices.

The Role of NMR and Mass Spectroscopy in Glycan Analysis

Geoff Carr is the Director of Analytical Development at Patheon located in Mississauga, Ontario. His email is geoff.carr@patheon.com.

The author describes how liquid chromatography-mass spectrometry works and explains some of its advantages and disadvantages, particularly compared to high-performance liquid chromatography.

Using Tandem LC-MS for Cleaning Validation

Cadnel Detchou, Analytical Bio-Chemistry Laboratories

Rowel Tobias, Analytical Bio-Chemistry Laboratories

John Anders, Analytical Bio-Chemistry Laboratories

The authors describe two applications of a modified mass-spectrometry (MS) method, multiple reaction monitoring (MRM-MS), in biopharmaceutical analysis.

Multiple Reaction Monitoring–Mass Spectrometry for Biopharmaceutical Analysis

This article presents the successful analysis of metabolic products from microsomal incubations of a common pharmaceutical compound.

Simultaneous Quantitative and Qualitative Measurements in Drug-Metabolism Investigations

Tadayuki Yamaguchi, Shimadzu Scientific Instruments

The authors present an analysis of ibuprofen based on United States Pharmacopeia General Chapter  “Chromatography” using high-performance liquid chromatography.

Ultra-High-Speed Analysis of Ibuprofen Using HPLC

Harald Fischer is with WITec, Ulm, Germany.

The authors describe how a combination of imaging techniques can be used to provide topographic and chemical information to characterize a sample.

Characterization with Atomic Force Microscopy, Topographic, and 3D Raman

Shimadzu's LCMS-8040 combines newly improved ion optics and collision cell technology with proprietary ultrafast technologies.

The world's fastest LCMS/MS tandem mass spectrometer

New product reviews for March 2013, featuring automation, IT, and process control systems.

Product Spotlight: Automation/IT/Process Control

New systems that combine Raman spectroscopy with automated imaging support the efficient gathering of such data, including information concerning size and shape distributions for individual components within a formulation.

Combining Spectroscopy with Automated Imaging: A New Analytical Solution to Meet Regulatory Requirements for Inhaled Products

F.C. Girard, PhD, is CEO of Spinnovation Analytical.

The author discusses current expectations in bioprocessing and lays a framework for using NMR to enhance a QbD approach.

Bio/Pharmaceutical Analysis Techniques