Analytics

Cadnel Detchou, Analytical Bio-Chemistry Laboratories

Rowel Tobias, Analytical Bio-Chemistry Laboratories

John Anders, Analytical Bio-Chemistry Laboratories

Articles

The authors describe two applications of a modified mass-spectrometry (MS) method, multiple reaction monitoring (MRM-MS), in biopharmaceutical analysis.

Multiple Reaction Monitoring–Mass Spectrometry for Biopharmaceutical Analysis

This article presents the successful analysis of metabolic products from microsomal incubations of a common pharmaceutical compound.

Simultaneous Quantitative and Qualitative Measurements in Drug-Metabolism Investigations

Shimadzu's LCMS-8040 combines newly improved ion optics and collision cell technology with proprietary ultrafast technologies.

The world's fastest LCMS/MS tandem mass spectrometer

New product reviews for March 2013, featuring automation, IT, and process control systems.

Product Spotlight: Automation/IT/Process Control

In the Spotlight August 2012

Amy Ritter was Scientific Editor, BioPharm International.

Extensive physicochemical characterization of the innovator product and the proposed biosimilar provides the foundation for demonstrating biosimilarity.

Looking for Fingerprints: Bioanalytical Characterization of Biosimilars

In the Spotlight April 2012

Combining olfactometry analysis with multidimensional gas chromatography–mass spectrometry provides an extremely useful analytical method for identifying aroma or odor notes from a sample.

An Analytical Technique for Identifying Tribromoanisole

Sanjay Garg, PhD, is an associate professor at the School of Pharmacy, University of Auckland, Auckland, New Zealand, and a member of the Pharmaceutical Technology Editorial Advisory Board.

A book about pharmaceutical analysis engages the reader with history and unexpected asides.

A Peak in Mass-Spectrometry Literature

Asish B. Chakraborty is a senior scientist at Biopharmaceutical Sciences, Waters Corporation, 34 Maple Street, Milford, MA 01757.

Weibin Chen is a principal research chemist at Biopharmaceutical Sciences, Waters Corporation, 34 Maple Street, Milford, MA 01757.

John C. Gebler is a senior scientist at Biopharmaceutical Sciences, Waters Corporation, 34 Maple Street, Milford, MA 01757.

The authors developed a method to accurately measure the average molecular weight of large poly(ethylene glycols) (PEGs) using ion-mobility time-of-flight mass spectrometry coupled with gas-phase ion–molecule reactions.

Improved Mass Determination of Poly(ethylene glycols) by Electrospray Ion-Mobility Time-of-Flight Mass Spectrometry Coupled with Ion–Molecule Reactions

Bio/Pharmaceutical Analysis, Mass Spectrometry