Analytics

Articles

Thermo Scientific TruTools chemometrics package extends the capabilities of the portable TruScan RM Raman Analyzer.

Chemometrics Software Expands Use of Raman Analyzer

The European Pharmacopoeia rewrites in its general chapter on Raman spectroscopy.

European Pharmacopoeia Revises Raman Spectroscopy Chapter

The BallProbe from MarqMetrix is an optical sampling interface for inline, real-time measurements.

Raman Immersion Probe Measures Samples Inline

Randi Hernandez was science editor at Pharmaceutical Technology from September 2014 to May 2017.

MedImmune will provide funds and access to monoclonal antibodies to seven postdoctoral associates for the creation of protein measurement and characterization tools.

NIST Partners with MedImmune on Protein Characterization Venture

Harald Fischer is with WITec, Ulm, Germany.

The authors describe how a combination of imaging techniques can be used to provide topographic and chemical information to characterize a sample.

Characterization with Atomic Force Microscopy, Topographic, and 3D Raman

New systems that combine Raman spectroscopy with automated imaging support the efficient gathering of such data, including information concerning size and shape distributions for individual components within a formulation.

Combining Spectroscopy with Automated Imaging: A New Analytical Solution to Meet Regulatory Requirements for Inhaled Products

Paul Kippax is a product manager, Laser Diffraction, Malvern Instruments Ltd., Enigma Business Park, Grovewood Road, Malvern Worcestershire, UK WR14 1XZ, Paul.Kippax@malvern.co.uk.

Deborah Huck is Product Technical Specialist – Morphological Imaging Systems, Malvern Instruments.

Carl Levoguer is Sales Specialist – Analytical Imaging Systems, Malvern Instruments.

Anne Virden is Product Technical Specialist – Diffraction, Malvern Instruments.

Julie Suman is President at NextBreath LLC, USA.

The way in which a suspension nasal spray product interacts with the body depends not only on the droplet size of the delivered droplet, but also on the particle size of the suspended API.

Characterizing A Nasal Spray Formulation From Droplet To API Particle Size

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Nanotechnology is an important area of drug and biomedical research, and advancing nano-analysis is crucial for its further development.

Exploring the Tools in Nanoparticle Analysis

Asish B. Chakraborty is a senior scientist at Biopharmaceutical Sciences, Waters Corporation, 34 Maple Street, Milford, MA 01757.

Weibin Chen is a principal research chemist at Biopharmaceutical Sciences, Waters Corporation, 34 Maple Street, Milford, MA 01757.

John C. Gebler is a senior scientist at Biopharmaceutical Sciences, Waters Corporation, 34 Maple Street, Milford, MA 01757.

The authors developed a method to accurately measure the average molecular weight of large poly(ethylene glycols) (PEGs) using ion-mobility time-of-flight mass spectrometry coupled with gas-phase ion–molecule reactions.

Improved Mass Determination of Poly(ethylene glycols) by Electrospray Ion-Mobility Time-of-Flight Mass Spectrometry Coupled with Ion–Molecule Reactions

A new Raman spectroscopic method to detect magnesium stearate in powder blends and tablets is described. High-volume pharmaceutical manufacturing requires the use of lubricants to facilitate tablet ejection from compressing machines. However, lubricants may also bring a number of undesired problems that have been widely documented in pharmaceutical scientific literature. New analytical methods are needed to understand lubrication and provide process knowledge in support of FDA's process analytical technology initiative. The detection of magnesium stearate in lactose, mannitol, corn starch and other commercially important excipients is reported. The Raman spectroscopic method has a detection limit of about 0.1% (w/w) based on the 2848 cm-1 band that corresponds to the symmetric stretch of the methylene group in magnesium stearate.

Bio/Pharmaceutical Analysis, Raman