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Articles

ABB’s modeling software, Shop Floor Integration V2.0, allows engineers to validate the connection of existing pharmaceutical manufacturing equipment with Werum’s PAS-X manufacturing execution system in a simulation prior to running it live. 

Digital Twin Modeling Software Facilitates Interface of Existing Equipment with an MES

Aaron Strand, PE is a senior research engineer with SPX FLOW, aaron.strand@spxflow.com

Nicolle Courtemanche is a senior application engineer with SPX FLOW, nicolle.courtemanche@spxflow.com

Aerobic bioprocesses are highly dependent upon the oxygen transfer rate (OTR) from sparged to dissolved gas. The relatively low solubility of oxygen, however, makes the choice of mixer impeller configuration a critical design factor for the bioreactor vessel. This article describes a series of experiments and computational fluid dynamics (CFD) simulations to detail the effect of mixer configuration on the efficiency and effectiveness of a bioreactor vessel with respect to blend time and mass transfer.

Impact of Agitator Design on Bioreactor Performance

Lennart Eriksson, PhD, is senior lecturer and data scientist at Sartorius Stedim Data Analytics.

Chris McCready is lead data scientist at Sartorius Stedim Data Analytics

Advanced data analytics tools are used by industry to find the golden nuggets in historical data, to aid in process development, to fine-tune production, and to achieve long-term improvements in product quality and throughput.

Characterizing a Bioprocess with Advanced Data Analytics

InstantGMP INV is a validated software for real-time material tracking and inventory control in biopharmaceutical manufacturing. 

Inventory Management Software Designed for Biopharma

Don DiPalma is director of Quality and Technical Services at LabVantage, lvsinfo@labvantage.com.

Jeff Vannest is senior director of Product Management at LabVantage.

Integrated computerized systems for data collection improve data security and offer a solution for handling temporary data.

Integrated Systems Aid Data Integrity

Proteus Digital Health is collaborating on a pipeline of digital, oral solid-dosage drugs for various therapies, including cardiovascular and oncology drugs, based on its first NDA, which used ingestible sensors in an antipsychotic treatment.

Proteus is Extending the Reach of the Digital Pill

Jennifer Markarian is manufacturing reporter for Pharmaceutical Technology.

The pharmaceutical industry is adopting Industry 4.0 and emerging technologies to improve product quality and manufacturing efficiency.

Modernizing Pharma Manufacturing

Pharma 4.0 envisions highly efficient automated processes, which could be continuous, batch, or a hybrid of these, driven by an integrated manufacturing control strategy. 

Pharma 4.0

Sensors and devices being developed by nGageIT Digital Health Solutions can track patient use of oral solid-dosage or injectable drugs. 

Sensor Technology Aims to Improve Medication Adherence

Agnes Shanley is senior editor of Pharmaceutical Technology.

Can an Irish analytics company and its CEO bring pharma closer to 21st-century practice?

Data and Artificial Intelligence