Advancements in personalized medicine and other innovations are transforming the way dosage forms are viewed.

Reshaping Dosage Forms

This study aimed to develop a taste-masked drug resin complex using the ion exchange resin Kyron T-114.

Development of Taste-Masked Oral Dispersible Tablets of Cefpodoxime Proxetil

Novel genetic engineering technologies are transforming the design and manufacture of bispecific antibodies, which are emerging as a promising new class of biologics.

Frontrunners in Bispecific Antibodies

Topic

Irwin Silverstein, PhD, is vice-president and chief operating officer at International Pharmaceutical Excipients Auditing, 1655 N. Fort Myer Drive, Suite 700, Arlington, VA 22209, tel. 703.351.5266.

Articles

The author discusses key areas of focus and presents best practices from the International Pharmaceutical Excipients Council (IPEC).

Excipient Quality and Selection

Wear-resistant materials and coatings protect tablet punches and dies from abrasive formulations.

Choosing Tableting Tooling for Compressing Abrasive Formulations

The syriQ Rigid Cap (SRC) and SCHOTT TopPac Rigid Cap (TRC) closure systems from Schott use an intuitive twist-off mechanism for ease of use and container closure integrity.

Prefillable Syringe Closure Systems Enhance Usability

Hovione will operate a commercial-scale continuous manufacturing facility in New Jersey as part of an agreement with Vertex Pharmaceuticals.

Hovione Plans Commercial Continuous Manufacturing Facility

Dedusting equipment and techniques address problems associated with tablet manufacturing dust accumulation.

Addressing Dust Accumulation in Tablet Manufacturing

Asking the right questions is crucial to establishing a biopharmaceutical facility design.

Designing a Biomanufacturing Facility Incorporating Single-Use Technologies

Randi Hernandez was science editor at Pharmaceutical Technology from September 2014 to May 2017.

The pharma company revealed in a fourth quarter call that it will improve its cell-culture capabilities by focusing on the use of naïve, highly proliferative cells to manufacture its CAR-T drug candidate.

Kite Pharma Stresses Importance of Cell-Culturing Techniques

The author lists five key areas to consider when selecting a CDMO to develop highly potent formulations.

Outsourcing Formulation Development for High-Potency Compounds

Matt Bundenthal is direct sales and communications manager at Fette Compacting America, www.fetteamerica.com .

Tablet presses require regular inspection and maintenance to prevent premature wear and tableting problems.

Best Practice: Preventive Maintenance Keeps Tablet Presses Running Smoothly

Richard Denk is Head Sales Containment at SKAN AG, www.skan.ch, Richard.Denk@skan.ch.

Manufacturing of antibody drug conjugates requires high-containment solutions, such as high-performance aseptic isolators.