Advancements in personalized medicine and other innovations are transforming the way dosage forms are viewed.

Reshaping Dosage Forms

This study aimed to develop a taste-masked drug resin complex using the ion exchange resin Kyron T-114.

Development of Taste-Masked Oral Dispersible Tablets of Cefpodoxime Proxetil

Novel genetic engineering technologies are transforming the design and manufacture of bispecific antibodies, which are emerging as a promising new class of biologics.

Frontrunners in Bispecific Antibodies

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Articles

The new sugars are touted to increase the efficacy of active pharmaceutical ingredients and improve cell culture yield.

Avantor Unveils New Sugars at CPhI

Cell Therapy Catapult will provide manufacturing scale-up services to enable Asterias’ future clinical trials and commercial supply for Asterias’ allogeneic dendritic cell immunotherapy, AST-VAC2.

Cell Therapy Catapult to Develop Process for Asterias Biotherapeutics

Randi Hernandez was science editor at Pharmaceutical Technology from September 2014 to May 2017.

Data protection for biologics is reduced from 12 to five years as a result of the Trans-Pacific Partnership agreement.

TPP Discussions Conclude; Biologics Now Have Shorter Data Protection Periods

The Cell History File is designed as a “cell passport” for developers and manufacturers of tissue- and cell-based medicinal products.

Cell Therapy Catapult Launches Cell History File

Probiodrug has signed an agreement with Rentschler Biotechnologie GmbH for the development of PBD-C06, a pGlu-Abeta-specific monoclonal antibody, as treatment for patients with Alzheimer’s disease.

Probiodrug Signs Manufacturing Agreement with Rentschler for Monoclonal Antibody PBD-C06

Jennifer Markarian is manufacturing reporter for Pharmaceutical Technology.

The challenge of achieving zero visible defects (i.e., particulates) in parenteral drugs will require a coordinated effort at all stages of the supply chain, particularly in the production and filling of primary containers.

Partnering to Address Particulates

The PDA report discusses qualification and operational handling of passive thermal protection systems.

PDA Releases Report on Passive Thermal Protection Systems

3M and Impel will collaborate to develop and commercialize Impel’s Precision Olfactory Delivery technology for enhanced central nervous system drug delivery.

Impel and 3M Partner to Advance Olfactory Drug Delivery

Multi-faceted powder characterization, including measurement of dynamic properties, can be used to correlate powder properties and process performance to support equipment selection, optimization, and troubleshooting.

Identifying Powder Properties that Define Process Performance

Hallie Forcinio is packing editor for Pharmaceutical Technology and Pharmaceutical Technology Europe, editorhal@sbcglobal.net.

Manufacturers of parenteral drugs face challenges to increase efficiency, control particulates, control extractables and leachables, and eliminate product/package interactions; new containers and packaging equipment offer increased options.