Advancements in personalized medicine and other innovations are transforming the way dosage forms are viewed.

Reshaping Dosage Forms

This study aimed to develop a taste-masked drug resin complex using the ion exchange resin Kyron T-114.

Development of Taste-Masked Oral Dispersible Tablets of Cefpodoxime Proxetil

Novel genetic engineering technologies are transforming the design and manufacture of bispecific antibodies, which are emerging as a promising new class of biologics.

Frontrunners in Bispecific Antibodies

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Articles

NIR Prediction of Solid Dosage Form Dissolution Profiles - Foss Whitepaper

Extending Calibrations for Near-Infrared Assay of Tablets Using Synthetic Modeling and Variance from Placebos - Foss Whitepaper

Cooling water is a critical component in the research and development, bulk manufacturing, and packaging of pharmaceuticals.

Reducing Energy and Water Use in Process Cooling

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Baxter International (Deerfield, IL), sanofi aventis (Paris), and Novartis (Basel, Switzerland) provided updates last week of their production and regulatory activities relating to preparedness in supplying the A(H1N1) pandemic influenza vaccine. Novartis also outlined its activities for providing seasonal flu vaccines.

Companies Update Activities for Pandemic and Seasonal Flu Vaccines

The authors prepared granules containing cinnarizine using polyethylene glycol 6000 as a melting binder and lactose monohydrate as hydrophilic filler. The effects of binder concentration and size were studied.

Formulation and Process Optimization of Cinnarizine Fast-Release Tablets

Angie Drakulich was editorial director of Pharmaceutical Technology.

Two years ago, the US Food and Drug Administration's Office of Generic Drugs (OGD) developed and implemented a program to test question-based reviews for abbreviated new drug applications (ANDAs). OGD is reviewing the benefits and challenges faced by pharmaceutical firms involved in the initiative to see what changes need to be made going forward.

FDA's Dr. Srinivasan Discusses Question-based Reviews for Generic Drugs

The Federal Trade Commission (FTC) last week issued an interim report that examined the effects of authorized generics on competition in the prescription drug market.

FTC Issues Report on Authorized Generics

Michelle Hoffman, editorial director of Pharmaceutical Technology.

A Pharmaceutical Technology report looks at trends in biopharmaceutical manufacturing. This article contains bonus online-exclusive material.

The Biopharmaceutical Manufacturing Survey

High-potency manufacturing of active pharmaceutical ingredients is a growing and specialized capability.

Examining High-Potency API Manufacturing

The authors discuss how strategic outsourcing to contract manufacturing organizations that have technical and regulatory expertise can add further value during vaccine development.