Advancements in personalized medicine and other innovations are transforming the way dosage forms are viewed.

Reshaping Dosage Forms

This study aimed to develop a taste-masked drug resin complex using the ion exchange resin Kyron T-114.

Development of Taste-Masked Oral Dispersible Tablets of Cefpodoxime Proxetil

Novel genetic engineering technologies are transforming the design and manufacture of bispecific antibodies, which are emerging as a promising new class of biologics.

Frontrunners in Bispecific Antibodies

Topic

Articles

Merck KGaA completes the divestment of its biosimilars business as part of its strategy to focus on developing a pipeline of innovator drugs.

Merck KGaA Completes $788-Million Divestment of Biosimilars Business

Jennifer Markarian is manufacturing reporter for Pharmaceutical Technology.

Continuous twin-screw granulation offers several options for increasing production scale. Thermo Fisher Scientific explains factors to consider in scale-up projects for manufacturing oral solid-dosage drugs. 

Scaling Up a Continuous Granulation Process

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Drug repurposing, repositioning, and rescue can be faster, cheaper, and target more diseases than traditional drug discovery approaches.

Expediting the Discovery and Development of Drugs

Poonam Sheth is a research scientist at Recipharm.

Matthew T. Marmura is a research scientist at Recipharm.

Considerations in selecting a dosage form for drug delivery to the lungs.

Targeting the Lungs

Ad Gerich is managing director, InProcess-LSP, The Netherlands

Michiel Damen is application specialist, InProcess-LSP, The Netherlands.

Willy Verhoeven is senior scientist, Polymeric Dosage Forms, MSD Oss, The Netherlands.

Sai Prasanth Chamarthy is associate director, Respiratory Product Development, Merck & Co, Rahway, NJ USA.

Rut Besseling is director, Science and Technology, InProcess-LSP, The Netherlands.

This study shows that the presence of API lumps can be detected by inline NIR, and elaborates on why NIR sensor dimensions and actual measured sample volume by the NIR sensor are important variables for adequate interpretation of obtained results.

Detection of Lumps in Powder Blends by Inline NIR

Vince Russell is director of Respiratory Discovery at Aptuit, www.aptuit.com/drug-design-and-discovery/therapeutic-areas/respiratory.Â 

Pulmonary drug delivery is becoming increasingly used. When developing pulmonary drugs, pharmaceutical chemists must consider drug absorption, control of particle size, suitable toxicology models, and patient compliance. The author reviews the issues specific to developing drugs designed for pulmonary delivery and considers how-with the right knowledge and expertise-these challenges can be overcome.

Four Challenges for Pulmonary Drug Delivery

Carolina Diaz Quijano, PhD, is manager of Innovation and Technical Marketing Nutra/Pharma at Omya International AG, Baslerstrasse 42, 4665 Oftringen, Switzerland, info.pharma@omya.com.

Functionalized calcium carbonate provides high porosity, which enables fast disintegration, and excellent compactibility that results in harder tablets at low compression forces. 

A Multifunctional Mineral Excipient

The acquisition of Protein Sciences, a vaccines biotechnology company, strengthens Sanofi’s influenza vaccines portfolio.

Sanofi Closes Acquisition of Protein Sciences

FDA halts unproved stem-cell cancer treatments administered to California patients, which was derived from a commercially unavailable military-grade vaccine.

FDA Seizes Military Vaccine Used in Unauthorized Stem-Cell Treatments

Hallie Forcinio is packing editor for Pharmaceutical Technology and Pharmaceutical Technology Europe, editorhal@sbcglobal.net.

Sensors and communication capability support proper usage, improve compliance, and may enable telemedicine. 