Development

Articles

We're all familiar with traditional pills and medicines, but how about medicated chewing gum? Marc Ribe of Cafosa Gum explains how APIs can be incorporated into a novel dosage form that can aid patient compliance.

Chewing Over API Challenges

The authors examine an oral-absorption-enhancement technology based on surface-active materials to increase apical membrane fluidity in vitro.

Oral-Absorption-Enhancing Drug-Delivery Technology

The authors describe the various available technologies used in orally disintegrating tablets.

Orally Disintegrating Tablets: The Effect of Recent FDA Guidance on ODT Technologies and Applications

The authors review various oral drug delivery systems that have been explored to increase patient compliance for insulin.

Novel Approaches for Oral Insulin Delivery

The authors review the solution and powder properties of polyethylene oxide and its various applications in hydrogels and hydrophilic matrix systems.

High Molecular Weight Polyethylene Oxide-Based Drug Delivery Systems - Part I: Hydrogels and Hydrophilic Matrix Systems

Ramesh Panchagnula, PhD, is a professor in the department of pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector-67, Ph-X, SAS Nagar-160 062, Punjab, India, tel. -91 172 214 682 or 214 687, fax -91 172 214 692.

The authors investigate whether an extrusion-spheronization proces can be used to develop a matrix-based, controlled-release formulation for a highly water-soluble drug.

Controlled-Release Dosage Forms for Diltiazem Hydrochloride

Kilambi Pundarikakshudu, PhD, is a professor at Shree S.K. Patel College of Pharmaceutical Education and Research, "Ganpat Vidyanagar."

The study presented in this article used a controlled-porosity osmotic pump, which was prepared in the form of a bilayered tablet containing a drug compartment and an osmogen layer for the delayed release of diltiazem HCI.

The Fabrication And Evaluation of the Formulation Variables of a Controlled-Porosity Osmotic Drug Delivery System with Diltiazem Hydrochloride

Mansoor A. Kahn, RPh, PhD, is a professor of pharmaceutical sciences and the director of the graduate program at Texas Tech University HSC School of Pharmacy, 1300 Coulter, Amarillo, TX 79106, tel. 806.356.4000 ext. 285, fax 806.256.4034.

Insulin is one of the most popular proteins to be studied for oral delivery. The authors review the current status of the development strategies of insulin drug delivery systems, the various challenges associated with these systems, and how these challenges may be overcome.

Formulation and Drug Delivery, Solid Dosage