Drug Development

Lyndsey Johnson, PhD, is a project scientist and program manager for IntraStem at Locate Bio Limited

James E. Dixon, PhD, is an assistant professor at the University of Nottingham

Kevin M. Shakesheff,* PhD, is a professor at the University of Nottingham and also chief scientific officer at Locate Bio

Articles

Intracellular strategies offer an effective alternative approach to deliver a range of therapeutic proteins. 


Advanced Cell Penetrating Peptide Systems for Gene Therapy

Gayatri C.Patel, M.Pharm, PhD, is associate professor in the Department of Pharmaceutics & Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy at the Charotar University of Science and Technology, Changa Campus, Changa- 388 421, Anand, Gujarat, India, gayatripatel.ph@charusat.ac.in, +91 2697 265162.

Chintan Patel is a researcher in the Department of Biotechnology, Zydus Research Centre, Cadila Healthcare Ltd., Ahmedabad, Gujarat, India. 

Sanjay Bandyopadhyay, PhD, is vice-president in the Department of Biotechnology, Zydus Research Centre, Cadila Healthcare Ltd., Ahmedabad, Gujarat, India

It is important to address manufacturing problems associated with the shorter shelf-life of pegylated L-asparaginase (pegaspargase) upon long-term storage in the form of a solution. 

Degradation Pathways: A Case Study with Pegylated L-Asparaginase

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Confidence in the quality systems and scientific competence of the API manufacturing team is essential.

Select Suppliers with Demonstrated Expertise to Avoid Sourcing “Bad” APIs

Felicity Thomas is the former Associate Editorial Director of Pharmaceutical Technology, Pharmaceutical Technology Europe, BioPharm International.

Easier access to information, targeting smaller patient populations, and increased regulatory focus on patient outcomes are driving patient‑centric drug development.

Patient‑Centric Drug Development Comes of Age

Flexibility and well considered manufacturing approaches could help tablet manufacturers face the increasing pressure resulting from the shifting bio/pharma development landscape.


Under Pressure

Kelly Boyer is general manager, Film Coatings at Colorcon Inc.

Market demand and regulatory guidance continues to promote improved medication design.


Gilding the Pill

Beverly Nickerson, PhD, is an associate research fellow in analytical research and development at Pfizer Inc., Eastern Point Road, Mail Stop 4086, Groton, CT 06340, tel. 860.441.0668, fax 860.715.8004, beverly_nickerson@groton.pfizer.com.

Anster Charles was a graduate student at the University of Missouri’s Chemistry Department, Columbia, MO.

Carlos Lee works for Lyndra Therapeutics, Watertown, MA.

Gail Johnson works for Pfizer Worldwide Research and Development in Groton, CT.

John Warzeka works for Pfizer Worldwide Research and Development in Groton, CT.

Laboratory testing found that a novel approach reduced the time required for sample preparation from hours to minutes. This article summarizes test methods and results.

Speeding Sample Preparation and API Extraction from Solid Oral Dosage Formulations

Philippe Gorria is senior director of Pharmaceutical Development at Recipharm.

Modified-release oral dosage forms can offer benefits to both formulation scientists and patients.

Modified-Release Formulations: Improving Efficacy and Patient Compliance

Researchers at the Georgia Institute of Technology developed a technique for administering contraceptive hormones through ‘pharmaceutical jewelry’. 

Pharmaceutical Jewelry Could Offer a New Family Planning Approach

The organizers of Pharmapack Europe have revealed their prediction that the drug delivery and healthcare packaging industry will experience significant growth during 2019.

Formulation and Drug Delivery