Drug Development

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Articles

Leveraging its global infrastructure, SAFC Supply Solution pilots a new external sourcing program.

SAFC Supply Solutions Rolls Out a New Business Model for Sourcing

Draft federal legislation that would require high-risk chemical facilities to use inherently safer technology for reducing their risk may present potential problems for custom and batch manufacturers supplying the pharmaceutical industry.

IST Measures Raise Concern for the Pharma Supply Chain

Stefan Schneid works in the Department of Pharmaceutics at the University of Erlangen in Erlangen, Germany.

Henning Gieseler, PhD, works in the Department of Pharmaceutics at the University of Erlangen, Erlangen, Germany 91058. tel. +49 9131 85 29545, gieseler@freeze-drying.eu.

Mannitol is the most commonly used bulking agent in freeze-drying formulation design. The benefit of using mannitol is that it crystallizes during freezing and permits drying processes at higher product temperatures, and thus with higher sublimation rates relative to purely amorphous systems (1). Mannitol, however, is known to form different crystalline modifications which compromises reproducibility of product characteristics and storage stability due to phase transformations (2, 3).

Peer-Reviewed Technical Note: Influence of Common Excipients on the Crystalline Modification of Freeze-Dried Mannitol

Contract manufacturers of APIs and intermediates are cautiously optimistic.

Changing Fortunes for CMOs

SAFC is delivering on its plan for double-digit annual growth by increasing its businesses through organic growth and targeted technology acquisitions.

SAFC Sets Forth an Ambitious Growth Strategy

Arvind K. Bansal is an associate professor at the National Institute of Pharmaceutical Education and Research, Sector-67, Phase-X, S.A.S. Nagar, Punjab 160062, India, tel 191 0 172 2214682 87, fax 191 0 172 2214692.

The selection of an appropriate salt form for a potential drug candidate is an opportunity to modulate its characteristics to improve bioavailability, stability, manufacturability, and patient compliance.

Salt Selection in Drug Development

The European Union's REACH initiative has the potential to affect the flow of chemicals into the pharmaceutical suppy chain.

A Changing Path in Global Sourcing

Show blasts off this month in Philadelphia with more suppliers, new trends, and real-world solutions.

Ingredients