Drug Development

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Articles

Aptuit expands its drug-development capabilities with the formation of Aptuit Laurus to take advantage of the growing pharmaceutical outsourcing market in India.

Aptuit Establishes New Company in India

Researchers forward approaches for catalytic hydroformylation, asymmetric hydrogenation, and biocatalysis to achieve enantioselectivity.

Advances in Asymmetric Synthesis

Appendix: definitions and regulations, Federal Food, Drug, and Cosmetic Act; Appendix: definitions and regulations, Title 21 Code of Federal Regulations; Appendix: definitions and regulations, Compliance Policy Guides

Supplements to the PQRI Workshop Results

The influence of magnesium stearate (MgSt) on powder lubrication and finished solid-dose properties presents big challenges to drug manufacturers.

Lubrication of Direct-Compressible Blends with Magnesium Stearate Monohydrate and Dihydrate

This article presents collaborative positions among excipient manufacturers, drug product manufacturers, and members of the US Pharmacopeia on key issues pertaining to the control of pharmaceutical excipients stemming from a recent Pharmaceutical Quality Research Institute workshop.

Joint Position Paper on Pharmaceutical Excipient Testing and Control Strategies

Fiera Milano Rho Exhibition Centre, Milan, Italy 2–4 October 2007

CPhI/ICSE/P-MEC 2007 show preview

A new economical method for producing fast-melting lamina-like dosage forms.

A partially freeze-dried lyophilization technology for producing fast-melting tablets

This article investigates how the industry can test inhalers in a way that is most representative of typical use.

Testing Inhalers

This article describes how rapidly disintegrating tablets containing a large quantity of an intensely bitter drug were successfully developed with a suitable level of masking, tablet hardness, disintegration property, dissolution profile and mouth feel.

Preparing rapid disintegrating tablets containing taste-masking microgranules

A new Raman spectroscopic method to detect magnesium stearate in powder blends and tablets is described. High-volume pharmaceutical manufacturing requires the use of lubricants to facilitate tablet ejection from compressing machines. However, lubricants may also bring a number of undesired problems that have been widely documented in pharmaceutical scientific literature. New analytical methods are needed to understand lubrication and provide process knowledge in support of FDA's process analytical technology initiative. The detection of magnesium stearate in lactose, mannitol, corn starch and other commercially important excipients is reported. The Raman spectroscopic method has a detection limit of about 0.1% (w/w) based on the 2848 cm-1 band that corresponds to the symmetric stretch of the methylene group in magnesium stearate.

Ingredients