Drug Development

Ranga Velagaleti is the manager of laboratory and stability at BASF Corporation, 8800 Line Ave., Shreveport, LA 71106, tel. 318.861.8040, fax 318.861.8004, velagar1@basf-corp.com

Articles

The results of forced degradation studies indicate the need for alternatives to valerophenone as an internal standard calibration for quantifying ibuprofen in bulk drug and tablet assay samples.

Photosensitivity of Internal Standard Valerophenone Used in USP Ibuprofen Bulk Drug and Tablet Assay and Its Effect on the Quantitation of Ibuprofen and Its Impurities

Ashish A. Joshi, PhD, is a project coordinator at Roquette America Inc., 1417 Exchange Street, Keokuk, IA 52632, tel. 319.526.2219, ashish.joshi@roquette.com

Added functionality excipients facilitate the development of novel drug delivery methods and improve processing techniques.

Added Functionality Excipients: An Answer to Challenging Formulations

Lyn Hughes, PhD, is a global technical service manager for healthcare in the Process Solutions Groups at Rohm and Haas Company, Spring House Technical Center, 727 Norristown Road, Spring House, PA 19477-0904, tel. 215.641.7329, fax 215.619.1608, lhughes@rohmhaas.com

Some of the common problems faced by formulators and how using ion exchange resins may be able to solve them are discussed.

Ion Exchange Resins Unique Solutions to Formulation Problems

Gerad Bolhuis, PhD, is as associate professor in the Department of Pharmaceutical Technology at the University of Groningen in Groningen, The Netherlands.

Recent advances in spray-drying technology have led to the production of new directly compressible lactose grades with distinct advantages.

New Developments in Spray-Dried Lactose

Charles A. Signorino, PhD, is president of CS Associates, Inc., 600 Markley Street, Norristown, PA 19401, tel. 610.279.7450, fax 610.292.9722.

Recent technology improvements have made acrylics the preferred system for the aqueous enteric coating of tablets.

The Use of Acrylic Resins for Improved Aqueous Enteric Coating

The author describes a separation method for two active ingredients in the contraceptive pill with liquid chromatography UV detection.

An LC Method for the Separation and Determination of Ethynodiol Diacetate and Ethinyl Estradiol in Tablets

R. Christian Moreton, PhD, is vice-president of pharmaceutical sciences at Finnbrit Consulting and a member of Pharmaceutical Technology’s editorial advisory board.

The author suggests that an excipient's functionality can only be determined in the context of a specific formulation and manufacturing process.

Excipient Functionality

Dry powder inhalers are a well-accepted dosage form for pulmonary drug delivery and a wide variety are either currently available or in development. This article examines a premetered, capsule-based multidose inhaler for which different qualities of a-lactose monohydrate were screened.

Selecting Lactose for a Capsule-Based Dry Powder Inhaler

Pharmacist and professor of biopharmacy, Biopharmaceutics Department

Pascale Gauthier is a pharmacist and directs courses for the Biopharmaceutics Department, Faculty of Pharmacy

Previous articles have presented a general review of the different types of spheres that can be obtained with a rotary fluidized bed process.1,2 This two-part study focusses on lipid spheres that can be prepared using hydrogenated castor oil, as well as examining the feasibility of the process and the main characteristics of the spheres obtained.

Manufacture and Dissolution Studies of Lipid Spheres: Part I

Business Manager, pharmaceuticals and cosmetics, for Cerestar Food and Pharma Specialities Europe

Senior Specialist, pharmaceutical and cosmetics, for Cerestar Food and Pharma Specialities Europe

Erythritol is a bulk sweetener polyol that is suitable for a variety of reduced-calorie and sugar-free foods. It has been part of the human diet for thousands of years because of its presence in foods such as fruit, mushrooms and fermentation-derived products including wine, soy sauce and cheese. This article investigates the properties of erythritol and describes how it can be used as a pharmaceutical excipient.

Ingredients