Drug Development

Articles

The authors examine the use of various grades of direct-compression mannitol in direct-compression tableting process to evaluate the content uniformity of micronized APIs and excipients in a solid-dosage formulation.

Obtaining Stable Homogenous Mixtures with Micronized APIs

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Particle-engineering technologies, such as crystal design for crystallization and producting cocrystals, particle-size reduction, and amorphous solid dispersions, help to optimize delivery of a drug.

Seeking Solutions in Solid-State Chemistry

The long-awaited patent cliff that has loomed in the pharmaceutical industry for years has arrived in earnest in 2012, with more than $40 billion in 2011 brand sales facing loss of exclusivity.

Shifts in Pharma Capital Agendas

Bristol-Myers Squibb has initiated a voluntary recall of 10 lots of BiCNU (carmustine for injection) previously manufactured by Ben Venue Laboratories, a former, third-party contract manufacturer for the company, to the user level.

Bristol-Myers Squibb Issues Voluntary Recall of Carmustine for Overfilled Vials

A review of taints and odors in the pharmaceutical and consumer healthcare industries.

2,4,6-Tribromoanisole and 2,4,6-Trichloroanisole

Industry and academia advance novel approaches for achieving enanioselectivity.

Meeting Challenges in Asymmetric Synthesis

The authors investigate the tablet-coating process using a combination of different simulation techniques.

Peer Reviewed: Numerical Simulation of Tablet Coating

Pfizer has two manufacturing facilities in Germany for high-potency manufacturing, respectively in Freiburg and Illertissen. Pharmaceutical Technology's Executive Editor Patricia Van Arnum visited the facilities and spoke to the company about the design and operation of these facilities.

Plant Focus: High-Potency Manufacturing and Sustainability at Pfizer

The authors describe a QbD study that was performed to optimize a coating system.

Achieving Process Understanding and Control in Film Coating

The authors explain chemical transformations that are achievable through certain biocatalytic routes.

Ingredients