Dosage Forms

Jennifer Markarian is manufacturing reporter for Pharmaceutical Technology.

Articles

CDMOs offer expertise and capacity for spray drying.

Spray Drying Finds Growing Use for ASDs

Experts share best practices in designing, manufacturing, and scaling up dry powder inhaler and metered dose inhaler drug–device combination products for inhalation drug delivery. 

Considerations for DPIs and MDIs in Inhalation Drug Delivery

When designing and manufacturing a pMDI or DPI combination drug-delivery device, the commercial stage should be kept in mind from the beginning of development.  

Best Practices in Manufacturing Inhalation Drugs

Felicity Thomas is Associate Editorial Director of Pharmaceutical Technology, Pharmaceutical Technology Europe, BioPharm International.

The intranasal route of administration is showing clinical promise, particularly for COVID-19, but there are multiple hurdles to overcome to ensure successful formulation.

Getting a Nose for Vaccines

FDA granted orphan drug designation for imatinib in AER-901 for the treatment of patients with pulmonary arterial hypertension. 

FDA Grants Orphan Drug Designation to Aerami Therapeutics’s Imatinib

Signal Rx Pharmaceuticals, Crystec, and ADYA Consulting are collaborating on the development of an inhaled dry powder formulation of SF2523 to treat pulmonary fibrosis, lung cancer, and SARS-CoV-2 related illnesses.

Partnership Forms for Development of Inhalable Formulation to Treat Lung Cancer, Lung Fibrosis, and SARS-CoV-2 

Dosage form priorities are shifting to focus on user-friendliness, leading to greater engagement with outsourcing partners earlier in development timelines.

Putting the Patient at the Heart of Dosage Form Design

Sara Sefton is technical manager, pharmaceutical development, Vectura.

Fergus Manford is patent attorney, intellectual property, Vectura.

Tim Gardner is director, manufacturing and NPI, Vectura.

Andrew Walker is vice president, device development, Vectura.

The choice of delivery platform for inhaled drug products is contingent on API-related factors, as well as the development stage of the product. 

Integrated Approach Facilitates Inhalation Drug Development

Susana Saldanha, PharmD, is formulation development scientist at Hovione.

Beatriz Fernandes, MSc, is a formulation development scientist at Hovione

João Ventura, PhD, is director of Technology Development and Licensing at Hovione Technology.

Particle performance in a DPI can be optimized by fine-tuning the formulation and manufacturing process parameters.

Spray Drying as an Enabling Technology for Inhalation Drug Delivery

Vectura will provide preclinical development services for Incannex’s inhaled drug product for the treatment of traumatic brain injury.