Manufacturing

Articles

New software tools by Tecan, a provider of automated laboratory instruments and solutions, complement each other to enhance process monitoring of its liquid-handling platforms.

New Software Tools Enhance Real-Time Process Monitoring in Labs

FDA grants support US research in continuous manufacturing monitoring and control techniques for bio/pharmaceutical manufacturing at Rutgers, MIT, and Georgia Tech.

Three FDA Grants Support Research in Modernizing Pharmaceutical Manufacturing

Jennifer Markarian is manufacturing reporter for Pharmaceutical Technology.

Modern technologies, including Industry 4.0 and the Industrial Internet of Things, offer opportunities to increase biopharmaceutical manufacturing efficiency.

Industry 4.0 in Biopharmaceutical Manufacturing

Siemens will become a preferred supplier for Sartorius Stedim Biotech’s automation solutions, and SSB will create a globally standardized automation platform for its biopharmaceutical manufacturing systems. 

Sartorius Stedim Biotech and Siemens Collaborate on Automation

ABB’s modeling software, Shop Floor Integration V2.0, allows engineers to validate the connection of existing pharmaceutical manufacturing equipment with Werum’s PAS-X manufacturing execution system in a simulation prior to running it live. 

Digital Twin Modeling Software Facilitates Interface of Existing Equipment with an MES

Aaron Strand, PE is a senior research engineer with SPX FLOW, aaron.strand@spxflow.com

Nicolle Courtemanche is a senior application engineer with SPX FLOW, nicolle.courtemanche@spxflow.com

Aerobic bioprocesses are highly dependent upon the oxygen transfer rate (OTR) from sparged to dissolved gas. The relatively low solubility of oxygen, however, makes the choice of mixer impeller configuration a critical design factor for the bioreactor vessel. This article describes a series of experiments and computational fluid dynamics (CFD) simulations to detail the effect of mixer configuration on the efficiency and effectiveness of a bioreactor vessel with respect to blend time and mass transfer.

Impact of Agitator Design on Bioreactor Performance

Lennart Eriksson, PhD, is senior lecturer and data scientist at Sartorius Stedim Data Analytics.

Chris McCready is lead data scientist at Sartorius Stedim Data Analytics

Advanced data analytics tools are used by industry to find the golden nuggets in historical data, to aid in process development, to fine-tune production, and to achieve long-term improvements in product quality and throughput.

Characterizing a Bioprocess with Advanced Data Analytics

InstantGMP INV is a validated software for real-time material tracking and inventory control in biopharmaceutical manufacturing. 

Inventory Management Software Designed for Biopharma

Don DiPalma is director of Quality and Technical Services at LabVantage, lvsinfo@labvantage.com.

Jeff Vannest is senior director of Product Management at LabVantage.

Integrated computerized systems for data collection improve data security and offer a solution for handling temporary data.

Integrated Systems Aid Data Integrity

Proteus Digital Health is collaborating on a pipeline of digital, oral solid-dosage drugs for various therapies, including cardiovascular and oncology drugs, based on its first NDA, which used ingestible sensors in an antipsychotic treatment.

Data and Artificial Intelligence