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Rapid structural elucidation of compounds in complex mixtures is a powerful technique in metabolite, degradation and process control applications. The ability to follow the fragmentation pathway through sequential MSn transitions provides added confirmation and increases the selectivity for monitoring compounds of interest in a complex mixture. Previously, the limiting factors in applying this technique were sensitivity at MS4 and higher transitions, and the cycle time required to acquire multiple MSn spectra across a narrow LC peak. Recent developments in trapping, detection efficiencies and scan rates have reduced these limitations and enabled rapid characterization of multiple compounds from single chromatographic runs.

Maximizing Sample Information with High Sensitivity MSn and Fast Cycle Time on a Linear Ion Trap Mass Spectrometer

Tosoh has developed a new product - Toyopearl Toyoscreen that allows fast identification of the optimal resin for your sample. You can develop the optimal conditions for the separation in addition to the determination of the dynamic binding capacity. All the resins prepacked in these columns are real process resins concerning particle size. Results on the small columns can be scaled up to production.

Toyopearl Toyoscreen — For the Fast Identification of the Optimal Resin

Ultrafiltration is a pressure-driven membrane filtering process used to separate and/or purify dissolved or suspended particles from water and other liquids. Recent advances in materials and membrane manufacturing techniques have led to ultrafiltration playing a pivotal role in a number of biopharmaceutical processes, including protein concentration and blood for actionation. This article examines the criteria that should be considered when selecting membranes for such applications.

Selecting the Right Ultrafiltration Membrane for Biopharmaceutical Applications

Steve Hansen is a technical services director at MKS Methuen, 651 Lowell St., Methuen, MA 01844, tel. 978.682.4567 ext. 4646.

Measurements of lyophilization pressure are accurate only if the gauges that are used have been properly calibrated.

Laboratory Equipment and Instruments