Manufacturing

Jennifer Markarian is manufacturing reporter for Pharmaceutical Technology.

Articles

A presentation at the Leistritz Pharmaceutical-Nutraceutical Extrusion Seminar explained how simulation tools benefit the development process.

Simulating the Pharma Twin-Screw Extrusion Process

The ChargePoint Single Use Passive and ChargeBag create a single-use system for contained and sterile transfer of pharmaceutical powders between process steps or facilities.

Single-Use Containers for Sterile Transfer of Powders

The UK’s Centre for Process Innovation is collaborating with partners GSK and AstraZeneca to establish a continuous wet granulation manufacturing facility for small-scale development of oral solid-dosage pharmaceuticals.

CPI Builds Open Innovation Facility for Continuous Wet Granulation

3D printing offers a new design freedom for bio/pharmaceutical manufacturing: whether for “printing” a solid-dosage drug or for creating a piece of equipment for bio/pharmaceutical laboratories or manufacturing facilities. 

INTERPHEX 2019 Keynote Series Presents Session on 3D Printing in Pharma

In OSD continuous manufacturing, flexible batch sizes can optimize supply, but equipment and processing challenges are still being addressed. 

OSD Continuous Manufacturing Strategies

When specifying an automated powder transfer system for vacuum conveying of pharmaceutical powders, consider material properties, facility constraints, and designs to mitigate explosion.

Best Practices for Vacuum Conveying of Pharmaceutical Powders

Kevin Queensen is a mechanical engineer who works in Technical Service Support in Tooling and Tablets at Natoli Engineering Company, Inc.

Bill Turner is the technical service manager of Tooling and Tablets at Natoli Engineering Company, Inc.

Sticking and picking are common problems in tablet manufacturing. Considering tablet compression issues before tablet designs are finalized can prevent unanticipated problems during scale-up and full-scale production.

Solving Sticking and Picking Through Tablet Design

Felicity Thomas is Associate Editorial Director of Pharmaceutical Technology, Pharmaceutical Technology Europe, BioPharm International.

Flexibility and well considered manufacturing approaches could help tablet manufacturers face the increasing pressure resulting from the shifting bio/pharma development landscape.


Under Pressure

FDA guidance on quality considerations for continuous manufacturing should help advance implementation by providing clarity and giving companies more confidence to make investments in the new technology.

FDA Issues Draft Guidance on OSD Continuous Manufacturing

Matt Bundenthal is direct sales and communications manager at Fette Compacting America, www.fetteamerica.com .

Identify the warning signs and follow best practices for refurbishment to improve tablet press yields.

Manufacturing Equipment, Solid Dose Drugs