Manufacturing, Lyophilization

Lyophilization Cycle Optimization of Cell-Derived Products

March 02, 2015

While the optimization of a lyophilization cycle for a biologic relies on a well-characterized formulation, viscosity and aggregation after product reconstitution must also be carefully managed.

Particle Engineering for Bioavailability Enhancement

February 02, 2015

Determining Protein Oxidation Induced During Fill-Finish Operations

May 15, 2014

The effect of absorbed vapor-phase hydrogen peroxide on a lyophilized product Protein Z, was studied by spiking experiments with different amounts of hydrogen peroxide.

Freeze Drying Protein Formulations

May 02, 2014

Common challenges and key considerations when developing a freeze-drying cycle for protein pharmaceuticals.

Through-Vial Impedance Spectroscopy: A New In-Line Process Analytical Technology for Freeze Drying

April 02, 2014

A new process analytical technology based on impedance spectroscopy has potential applications for characterizing product attributes during the freeze-drying process.

Recipham to Expand Lyophilization Capacity in Germany

October 14, 2013

Recipharm has invested EUR 32 million ($43 million) in its Wasserburg, Germany site to expand lyophilization capacity.

Strong Prospects for Fill-Finish Contract Manufacturing

October 09, 2013

A recent market analysis offers a promising outlook for contract fill-finish and lyophilization services.

XstalBio Introduces CentuRecon

September 02, 2013

CentuRecon enables dry formulations of therapeutic proteins to quickly be prepared for injection at high concentration.

Controlling Ice Nucleation During the Freezing Step of Lyophilization

May 02, 2013

Lyophilization technologies for controlled nucleation.

Lyophilization: A Primer

May 02, 2013

Optimized freeze-drying cycles can offer scientific and business advantages.