Manufacturing

Articles

The author discusses the relative advantages and disadvantages of lyophilization in vials and dual-chamber systems.

Comparing Lyophilization in Vials and Dual-Chamber Systems

Contamination is almost always related to human error and there is a clear drive to reduce human implications in aseptic operations. This can be achieved in multiple ways.

Avoiding Contamination Risks in Aseptic Processes

We have changed the brand of our stoppers for a product that we freeze-dry in vials. Since the change, we have observed a significant increase in rejects for collapsed cakes. Why are the cakes collapsing? What can we do to prevent this problem?

Collapsed Cakes

The future, and increasingly the present, for aseptic operations is isolated robotics. Companies that wish to gain competitive advantages in their operations are stepping up and taking notice.

Isolated Robotics: The Future of Aseptic Operations

In our manufacturing process, we are running into issues with our vial stoppers clumping in the feeder bowl. How can we ensure that the stoppers go through smoothly without clumping up?

Vial Stoppers That Won't Stop Clumping

The authors discuss the preparation of lipophilic drug nanocrystals by controlled crystallization during freeze-drying.

Controlled Crystallization During Freeze-Drying

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

The article examines the drivers of customer perception of contract service providers of pharmaceutical development and manufacturing.

Customer Drivers Influencing Supplier Differentiation

PharmTech's monthly newsletter, Equipment and Processing Report, reviews the Editor's Picks for the June 2011 edition from Meissner and Telstar.

June 2011 Editor's Picks: Products from Meissner and Telstar

James E. Akers is the president of Akers Kennedy & Associates, PO Box 22562, Kansas City, MO 64113, akainckc@aol.com.

James P. Agalloco is the president of Agalloco & Associates, P.O. Box 899, Belle Mead, NJ 08502, tel. 908.874.7558, jagalloco@aol.com. He is also a member of Pharmaceutical Technology’s editorial advisory board.

The authors question certain aspects of the industry's current regulatory-compliance strategy and suggest that aseptic-process control and evaluation should be revised.

Regulation of Aseptic Processing in the 21st Century

A technical forum moderated by Patricia Van Arnum

Manufacturing, Parenterals and Injectables