Manufacturing

Articles

The author proposes techniques, based on Six Sigma methods, for monitoring such processes to discover their airflow patterns and reduce opportunities for spillage.This article is part of PharmTech's supplement "Solid Dosage and Excipients 2010."

Spillage Prevention and Airflow-Pattern Monitoring for High-Shear Process Operations

Thomas Paust is global director of marketing at Sartorius Stedim Biotech GmbH in Goettingen, Germany.

The authors describe the origins of single-use components and explain their application to aseptic processes. They also show how disposable devices have changed over time and offer a glimpse of the future.

The Evolution of Single-Use Technologies in Aseptic Processing

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Angie Drakulich was editorial director of Pharmaceutical Technology.

Leading experts share insight on the current and future direction of process analytical technology. This article contains bonus online material.

PAT: A New Dawn for Drug Product Quality

Endotoxin removal from a finished product is a major challenge for biopharmaceutical manufacturers; particularly as all endotoxin removal methods have operational limitations and may result in loss of protein.

Removing endotoxin from biopharmaceutical solutions

A look at the true cost-drivers of cell-culture production.

Debunking the Bottleneck Myth

The spotlight on the biopharmaceutical industry is intensifying, as recently evidenced by Pfizer's (New York) ongoing acquisition of Wyeth (Madison, NJ), which was initiated partly to reduce the former's dependence on small-molecule drugs.

The Shape of Biopharmaceutical Facilities to Come

Ultra high performance liquid chromatography is advantageous in a contract laboratory because it is faster, more sensitive, and relies on smaller volumes of organic solvents than HPLC.

Ultra High Performance Liquid Chromatography in the Contract Manufacturing Environment

Sanjay Garg, PhD, is an associate professor at the School of Pharmacy, University of Auckland, Auckland, New Zealand, and a member of the Pharmaceutical Technology Editorial Advisory Board.

A book about pharmaceutical analysis engages the reader with history and unexpected asides.

A Peak in Mass-Spectrometry Literature

Theodore H. Meltzer is principle of Capitola Consultancy.

A well-balanced guide to industrial bioseparations provides valuable information.

Bringing Certainties to a Burgeoning Field

The authors review methods for reducing analysis time and increasing throughput that are reliable and maintain data integrity.

Manufacturing, Process Chromatography