Manufacturing

Articles

Mylan completes expansion of its transdermal patch facility in Vermont.

Mylan Completes Expansion of Vermont Transdermal Patch Facility

New studies reveal the promise and feasibility of transdermal vaccine delivery.

Prophylaxis in a Patch

Private companies and universities are developing new ways to deliver protein drugs.

Needles' Days Are Numbered

In a draft guidance published this week, the US Food and Drug Administration recommended that makers of transdermal and transmucosal drug-delivery systems use "an appropriate scientific approach" during product design, development, and manufacturing to minimize the amount of residual drug substance present at the end of the products' labeled use periods.

FDA Recommends Reducing Residual Drug in Transdermal Delivery Systems

If you’ve worked in the drug industry for a while, chances are good that you remember Pfizer’s Rezulin, which was produced through hot melt extrusion (HME). If you work for a major pharmaceutical manufacturer, it’s likely that your company owns a twin-screw extruder. Yet HME has not been a common way of manufacturing drugs, and many industry employees don’t understand the principles of HME or the advantages that the technique offers.

Is Hot Melt Extrusion an Untapped Resource?

Instead of hampering progress, cost pressures might inspire Big Pharma to get creative.

Will 2009 Bring Innovation?

A microelectronic system based on radio-frequency (RF) cell ablation addresses limitations of other transdermal drug-delivery methods. This system expands the transdermal spectrum to include the delivery of water-soluble molecules, peptides, proteins, and other macromolecules.

Advances in Radio-Frequency Transdermal Drug Delivery

Transdermal delivery takes up once-forbidden compounds, reviving markets and creating formulation opportunities.

Advances in Transdermal Technologies

Transdermal drug technology specialists are meeting demands for methods that can painlessly deliver larger molecules in therapeutic quantities.

Breaking the Barrier: Advances in Transdermal Technology

Melinda S. Hopp is the director of marketing at Adhesives Research, Inc., 400 Seaks Run Rd., PO Box 100, Glen Rock, PA 17327, tel. 717.227.3456, fax 717.227.3484.

Adhesives manufacturers can be involved in the development of transdermal drug delivery products by working with pharmaceutical companies on R&D, materials qualification, manufacturing, and other product development tasks.

Manufacturing, Specialty Dosage Forms