Manufacturing

Kieran O’Connor is Analytical Science and Technology senior chemist at SK biotek, Ireland, kieran.oconnor@sk.com. (formerly Bristol Myers Squibb)

John Wasylyk is senior principal scientist at Bristol-Myers Squibb, USA; john.wasylyk@bms.com

Bob Wethman is senior research scientist II at Bristol-Myers Squibb, USA

Ming Huang is senior research investigator I at Bristol-Myers Squibb, USA

Articles

Spectroscopic-based control methods were introduced as equivalent alternative methods, first to a gas chromatographic method to monitor an in-process solvent exchange step and second to a potentiometric titration method to release a process input material for drug substance manufacturing. 

Spectroscopy Facilitates Lean Analysis

Felicity Thomas is Associate Editorial Director of Pharmaceutical Technology, Pharmaceutical Technology Europe, BioPharm International.

Technical advances in process understanding and control must be accompanied by a change in mindset.

Changing Perceptions: An Understanding of Lyophilization Advancements

New alert customization and expanded Open Platform Communication support in Emerson’s DeltaV Mobile app improve notification and third-party system monitoring.

Mobile App for Processing Plants Improves Data Access

Tornado Spectral Systems, winner of the 2018 CPhI Excellence in Pharma Award for Analysis, Testing, and Quality Control, discusses real-time process measurement for biopharmaceutical and small-molecule drug manufacturing. 

Raman Spectroscopy System Allows On-line Process Measurement

TrendMiner 2018.R2 software for analysis of time-series data includes the ContextHub platform for expanded, self-service analytics capabilities.

TrendMiner Updates Analytics Software

AqVida, winner of the 2018 CPhI Excellence in Pharma Award for manufacturing technology and equipment, identifies advantages of robotics compared to conventional automation in fill/finish operations. 

Robotic Automation Enhances Fill/Finish

Will Goetz is vice-president of Digital Transformation Practice, at Emerson, will.goetz@emerson.com

Ron Rossbach is Life Sciences Consultant for Emerson, ron.rossbach@emerson.com.

To improve production in pharmaceutical manufacturing, the IT, OT, and Quality functional groups must work together to get the most value from existing plant data.

Improving Production: How IT, OT, and Quality Can Collaborate

Jennifer Markarian is manufacturing reporter for Pharmaceutical Technology.

Collaborative robots work beside laboratory employees to improve efficiency in pharmaceutical research and quality control labs. 

Cobots in the Pharma Lab

Agnes Shanley is senior editor of Pharmaceutical Technology.

By reducing the number of assays needed and allowing product quality attributes to be measured end to end, MAM promises to allow users to gain product and process understanding much sooner than they could in the past, and to ensure quality and safety in a more efficient, streamlined way, throughout the product life cycle.

Multiple Attributes Monitoring: A New Phase in PAT for Biopharmaceuticals

Sean Bermingham is head of Formulated Products at Process Systems Enterprise, Ltd., 26-28 Hammersmith Grove, Hammersmith, London, UK, s.bermingham@psenterprise.com

Dana Barrasso is senior consultant at Process Systems Enterprise, Inc., 3 Wing Drive, Cedar Knolls, NJ, d.barrasso@psenterprise.com. 

Mechanistic process and product modeling turns data into knowledge that can be extrapolated with known confidence for design space characterization and risk assessment.

Process Control, Automation, and PAT