Dosage Forms

Johannes G. Khinast is professor at the Institute of Process and Particle Engineering, Graz University of Technology, Austria

Stephan Sacher is senior scientist at the Research Center for Pharmaceutical Engineering GmbH in Graz, Austria.

Elen Gartshein is senior manager at Pfizer Global Supply, Peapack, NJ, USA.

Matthias Wolfgang is scientist at the Research Center for Pharmaceutical Engineering GmbH in Graz, Austria.

Patrick Wahl is senior scientist at the Research Center for Pharmaceutical Engineering GmbH, Graz, Austria.

Articles

Optical coherence tomography can improve quality control and development of coated dosage forms by allowing film thickness to be measured in real time.

Real-Time Measurement of Coating Film Thickness

Pramote Cholayudth previously was the managing director of the Professional Conference Center, Ltd. He currently is a validation consultant to Biolab Co., Ltd., in Thailand. He is the founder and manager of PM consult, cpramote2000@yahoo.com.

This paper describes how the concept of acceptance value can be redefined to remove bias and more closely reflect quality targets.

Uniformity of Dosage Units, Part 1: Acceptance Value

Jennifer Markarian is manufacturing reporter for Pharmaceutical Technology.

Innovative technologies, such as drug-loaded devices and 3D printing, enable advances in implantable devices and other novel dosage forms.

New Dose Forms Focus on the Patient

Adeline Siew is editor for Pharmaceutical Technology Europe. She is also science editor for Pharmaceutical Technology.

Lipid-based formulations offer a means of addressing the physicochemical and biological challenges of poorly soluble APIs.

Developing Lipid-Based Formulations

3D printing is being explored as a manufacturing method for on-demand, personalized medicine.

Considering 3D Printing for Solid Dosage Forms

Senomyx uses an approach, known as taste-blocking, to address the challenges of bitter APIs. Kenneth J. Simone, vice-president of Pharmaceutical Business Development, Senomyx, speaks with Pharmaceutical Technology about this technology. 

Taste-Blocking—An Alternative to Tastemasking

The level of tastemasking required will depend on the API properties and the dosage form design.

Coating for Tastemasking

Paul Kippax is product manager at Malvern Instruments.

Jennifer Burt is applications specialist at Malvern Panalytical.

Carolyn O'Grady is UK applications manager at Malvern Panalytical.

This article examines IVBE testing requirements for topical creams and explores some of the analytical techniques necessary. 

Testing Topicals: Analytical Strategies for the In-Vitro Demonstration of Bioequivalence

Jeff Williamson is director of Product Development at Lonza.

API-in-capsule approaches enable pharmaceutical companies to quickly assess new drug candidates with reduced API consumption and to increase speed to clinic.

Application of API-in-Capsule Best Practices to Accelerate Drug Product Development

Sai V. Nudurupati is assistant director at AbbVie Inc. (North Chicago, IL)

Michael J. Kukulka is senior manager, Global Labeling, Regulatory Affairs, PRA Health Sciences (Deerfield, IL)

Takako Ono is principal scientist, Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Co. Ltd. (Osaka, Japan)

Haiyan Grady is associate scientific director CMCC, Takeda Development Center Americas, 300 Massachusetts Ave (4274), Cambridge, MA 02139, Tel: 1-224-554-2067, haiyan.grady@takeda.com

This article describes the approaches used during the development of a dexlansoprazole delayed-release orally disintegrating tablet (ODT) to evaluate tablet size and texture as they relate to disintegration rate and patient experience; in addition, the resistance to alcohol was also characterized. 

Solid/Semi-Solid Dosage