Dosage Forms

Articles

The market for tablet compression technology and the demands placed on equipment manufacturers have changed quite significantly in recent years.

Tablet compression: changing trends, more demands

We regularly deal with tabletting equipment problems and malfunctions, and find that the most common cause is misuse or improper handling and transportation, which often leads to accidental damage to tablet punches (including nicks and dents to the punch tip edges).

Tabletting equipment: common problems and how to avoid them

The market for tablet compression technology and the demands placed on equipment manufacturers have changed quite significantly in recent years. This has been driven by a number of factors.

The author outlines the key concepts of ISPE's recently revised Baseline Pharmaceutical Guide for New and Renovated Facilities. This article is part of a special supplement on Excipients and Solid Dosage.

Review of ISPE's Baseline Guide for Oral Solid Dosage Forms

Ana Rita Pires is a PhD student at the University of Porto (Portugal).

D. López Malo is junior researcher at the Department of Analytical Chemistry, University of Valencia (Spain).

J. Martínez Calatayud is Professor of analytical chemistry at the Department of Analytical Chemistry, University of Valencia (Spain) 

Testing the dissolution rates of a pharmaceutical formulation (also known as in vitro availability) aids drug quality control and is a compulsory requirement of the British, European and US pharmacopoeias.

Obtaining simultaneous multiple dissolution profiles of solid oral dosage formulations

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Tablets and capsules are mainstay product forms, so what are the spending and innovation trends for solid-dosage manufacturing equipment and machinery?

Tracking Solid-Dosage Equipment

Hsiang Yu Hsieh is a graduate student at National Central University, 300 Jhong-Da Rd., Jhong-Li City 320, Taiwan, ROC.

Yan Chan Su is a graduate student at National Central University, 300 Jhong-Da Rd., Jhong-Li City 320, Taiwan, ROC.

Hung Ju Hou is a graduate student at National Central University, 300 Jhong-Da Rd., Jhong-Li City 320, Taiwan, ROC.

In Part I of this article, which appeard in the March 2010 issue, the authors describe their approach for constructing form spaces for carbamazepine, cimetidine, and phenylbutazone by initial solvent screening to evaluate the feasibility of spherical crystallization. Part II of this article discusses their findings.

Spherical Crystallization for Lean Solid-Dosage Manufacturing (Part II)

Janie Dubois is Product Manager, Analytical Imaging, Malvern Instruments (USA).

Vibrational spectroscopy, which encompasses near-infrared, mid-infrared and Raman spectroscopy, is an important analytical tool in the pharma industry.

Choosing a spectroscopic system for tablet analysis

In Part I of this article, the authors describe the materials and methods used in developing a screening strategy to accelerate the preparation and characterization of spherical agglomerates by spherical crystallization.

Spherical Crystallization for Lean Solid-Dose Manufacturing (Part 1)

Stephanie Sutton was an assistant editor at Pharmaceutical Technology Europe.

Capsules that can release their contents at a selected temperature have been developed by researchers in France, and could lead to the development of therapeutic agents that are applied to the skin and triggered locally by rubbing.

Solid/Semi-Solid Dosage