Dosage Forms

Articles

A microelectronic system based on radio-frequency (RF) cell ablation addresses limitations of other transdermal drug-delivery methods. This system expands the transdermal spectrum to include the delivery of water-soluble molecules, peptides, proteins, and other macromolecules.

Advances in Radio-Frequency Transdermal Drug Delivery

For pediatric and geriatric patients, fast-dissolving drug-delivery systems provide an easier way to take medications and vitamins. Oral thin films have evolved to provide systemic delivery of active pharmaceutical ingredients for over-the-counter and soon, prescription drugs. The authors review the practical benefits of dissolvable films, their manufacture, and their market potential.

Dissolvable Films: Dissolvable Films for Flexible Product Format in Drug Delivery

Scientists at the University of North Carolina at Chapel Hill have successfully tested a new inhaled tuberculosis (TB) vaccine.

Promising Results Pave the Way to Inhaled TB Vaccine

Transdermal delivery takes up once-forbidden compounds, reviving markets and creating formulation opportunities.

Advances in Transdermal Technologies

The preferred route of administration for an injected therapeutic agent is subcutaneous (SC), but SC injections are generally limited to no more than 1-2 mL in volume, representing a major challenge, especially for large protein biologics.

Converting Intravenous Dosing to Subcutaneous Dosing With Recombinant Human Hyaluronidase

The book is written for drug-delivery scientists experienced in the dermatological or transdermal fields.

Getting under Our Skin: The Evolving Field of Transdermal Delivery

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Following the sales of its global branded pharmaceutical business, 3M stays the course in drug delivery as its Drug Delivery Systems Division advances technology in inhalation and transdermal drug delivery.

3M Drug Delivery Systems Advances Inhalation and Transdermal Drug Delivery

Hallie Forcinio is packing editor for Pharmaceutical Technology and Pharmaceutical Technology Europe, editorhal@sbcglobal.net.

Bringing Exubera to market requires extensive collaboration by Pfizer, Nektar Therapeutics, West Pharmaceutical Services Tech Group, and Bespak.

Special Packaging Delivers Inhaled Insulin

Bang & Olufsen Medicom (Copenhagen, Denmark, www.medicom.bang-olufsen.com), a drug-delivery device solutions provider, and Bespak (Milton Keynes, UK, www.bespak.com), a medical-devices and inhalation-valve technologies company, established an exclusive partnership to codevelop and comarket the ?Assist Actuated Inhaler,? a single-increment, dose-counting inhaler. The integrated device features an assisted firing mechanism for easier patient use, according to a company release.

Device Companies Unite for a Better Inhaler

Transdermal matrix-type patches of Nefopam hydrochloride with a combination of pressure-sensitive adhesives were developed. The polymeric composition provided a controlled and sustained release of the drug from the patches and demonstrated favorable physicochemical characteristics.

Specialty Dosage Drugs