Topic

Christopher Burgess, PhD, is managing director, Burgess Analytical Consultancy Limited, Barnard Castle, Co Durham, UK.

Articles

Do you have acceptable control of your instruments and analytical procedures?

Demonstrating a State of Control

Chris Burgess, PhD, is an analytical scientist at Burgess Analytical Consultancy Limited, ‘Rose Rae,’ The Lendings, Startforth, Barnard Castle, Co Durham, DL12 9AB, UK; Tel: +44 1833 637 446; chris@burgessconsultancy.com; www.burgessconsultancy.co

Performing a measurement uncertainty calculation is often seen as problematic.

Measurement Uncertainty without the Math

Statistical procedures give statistical answers not analytical judgement.

Is Your Calibration Really a Good Straight Line?

The choice of dilution schemes can minimize solution preparation errors.

How Accurate are Your Dilutions?

A risk-based guard band surrounds a specification limit and is derived from the uncertainty of the reportable value of the analytical procedure, which includes the uncertainty in the reference standard. The author discusses requirements for generating a reportable value and calculating the associated measurement uncertainty.

Using the Guard Band to Determine a Risk-Based Specification

Statistical analysis shows how much testing is needed to deliver a reliable estimate result.

Is a Sample Size of n=6 a 'Magic' Number?

This article takes a statistical look at the calibration requirements for a UV spectrometer.

Calibration of instruments: Is Your UV Spectrometer Accurate Enough

The Basics of Measurement Uncertainty in Pharma Analysis

The author discusses the purpose of analysis and testing and the implications for specifications and their underlying statistical distribution.

Evaluating Risk-Based Specifications for Pharmaceuticals

Compositing samples is appropriate under certain circumstances but raises caveats on how and when it should be applied.

Statistical Solutions