Bioanalytical Method Development For Lipids in LNP by LC-MS/MS

This webinar provides an insight into how a robust LC-MS/MS method development can be performed ensuring optimal method sensitivity to detect residual analytes.

Register Free: https://www.pharmtech.com/pt_w/bioanalytical

Event Overview:

Understanding biodistribution is critical for evaluating the bioequivalence, bioavailability, and toxicity of a drug substance (or excipients). Residual drug substances or excipients are analyzed in various biological matrices, such as blood, plasma, serum, and tissues. The choice of matrix is mainly dependent on the route of administration. This webinar will provide some insights into:

• Approaches taken during LC-MS/MS method development to ensure good method sensitivity
• Optimization of sample preparation with an emphasis on protein precipitation technique
• Ensuring method robustness before moving to validation

Key Learning Objectives

• Learn the process of LC-MS/MS method development.
• Learn the different sample preparation techniques used to deal with challenging biological matrices to attain target method sensitivity.
• Learn how to ensure method robustness with a focus on method validation.

Who Should Attend

• Analytical scientists
• Executives in charge of CMC

Speaker:

Uday Velagapudi, Ph.D.
Scientist III/Group Leader
Pace® Life Sciences

Uday Velagapudi is a Scientist III/Group Leader of Pharmaceutical Sciences at Pace® Life Sciences, an integrated CMC drug product development contract research organization. Uday is an SME focusing on method development for bioanalytical quantitation, small molecule and metabolite characterization, protein characterization, and host-cell protein analysis using low- and high-resolution LC-MS systems. Uday has authored or co-authored eight publications in reputable journals, such as Science and Journal of Medicinal Chemistry, and received his Ph.D. in Medicinal and Pharmaceutical Chemistry from St. John’s University in New York.

Register Free: https://www.pharmtech.com/pt_w/bioanalytical