Controlled Release from Porous Platforms

By Spomenka Simovic, Dusan Losic and Krasimir Vasilev

The authors present a method for controlling the release of therapeutics by applying a plasma polymer layer to the surface of porous materials. The current study applied this technique to the release of antibiotics and a protein. The approach substantially reduced the initial burst release and provided zero-order release kinetics. The method can be applied to any type of porous drug carrier because the techniques for depositing a polymer overlayer are independent of the substrate.