Optimizing Oral Osmotic Systems: Key Parameters and Polymer Insights

Osmotic pump tablets, particularly bilayer push‑pull systems (PPOP), enable zero‑order drug release with precise dosing independent of fed or fasted states. This webinar explores the key formulation and design levers critical to achieving robust, consistent drug delivery.

Register Free: https://www.pharmtech.com/pt_w/osmotic-pump

Event Overview:

Osmotic pump tablets are a proven controlled‑release technology designed to deliver drug products with zero‑order release profiles. By relying on osmotic pressure rather than physiological conditions, push‑pull osmotic pump (PPOP) systems enable precise and reproducible drug release that is largely independent of external variables such as a fed or fasted state.
Despite their advantages, developing robust PPOP formulations requires a deep understanding of the formulation and design levers that govern system performance. Factors such as excipient selection, polymer behavior, tablet architecture, and processing conditions all play a critical role in ensuring consistent drug delivery across development, scale‑up, and commercial manufacturing.

This webinar will examine the key formulation and design considerations essential for successful PPOP development. Particular focus will be given to the swelling behavior of polyethylene oxide (PEO), the impact of PEO molecular weight on push‑layer performance, and how these parameters influence drug release, robustness, and reproducibility. Attendees will gain practical insights into how excipient and design choices can be optimized to achieve reliable and controlled drug delivery.

Key Learning Objectives:

• Understand the advantages and limitations of osmotic pump tablets
• Identify formulation and design levers controlling PPOP drug release
• Explore PEO swelling mechanisms and molecular weight effects in push layers

Who Should Attend:

• Formulators
• Quality Professionals
• Drug Product Manufacturing Teams

Speakers:

Amalia Harumi-Arasawa
Customer Solutions Scientist
Roquette

Amalia Arasawa is a pharmaceutical scientist with more than 25 years of experience supporting customers throughout all stages of drug development and manufacturing. She has expertise in oral solid dosage forms, including formulation development, modified release systems, film coatings, taste masking, multiparticulates, and softgels. In her role as a Customer Solutions Scientist at Roquette’s Health & Pharma Solutions, she collaborates with pharmaceutical companies to address complex formulation challenges, translating excipient science into robust and scalable solutions. She holds a Bachelor’s degree in Pharmacy and Biochemistry from the University of São Paulo and a specialization in Business Administration from Fundação Getulio Vargas.

Meinolf Brackhagen, PhD
Senior Customer Solutions Scientist
Roquette

Dr. Meinolf Brackhagen is a Global Solutions Partner, Technical Services & Development (TS&D) at Roquette’s Health and Pharma Solutions Business Unit, where he leads technical service and development projects for pharmaceutical applications. He specializes in analyzing structure-property relationships to support product commercialization and customer projects. With over 20 years of R&D experience at various pharmaceutical and chemical companies — progressing into leadership roles — and more than a decade focused on pharmaceutical excipients and applications, he brings extensive industry expertise.

Dr. Meinolf holds a diploma in Organic Chemistry from TU Dortmund and a Ph.D. in Carbohydrate Chemistry from the University of Rostock. A certified Six Sigma Black Belt, he has authored or co-authored over 40 patent applications and eight peer-reviewed journal articles.

Register Free: https://www.pharmtech.com/pt_w/osmotic-pump