Single-Use Systems Expand Scale of Chromatography

Sartorius Stedim Biotech has expanded its range of single-use membrane chromatography solutions with Sartobind Cassettes, a pod-like modular system for commercial applications in both capture and polishing. The cassettes offer the same flow path, bed heights (4 and 8 mm), and void volume ratios as Sartobind capsules, and are compatible with quaternary ammonium (Q), sulfonic acid (S), salt-tolerant interaction chromatography primary amine (STIC PA), and phenyl ligands. The new design goes beyond the previous 5-L size limitation for capsule formats, expanding the boundaries of membrane chromatography. Multiple cassettes, each with 0.8-L or 1.6-L membrane volume, can be set up in three different stainless-steel holders, resulting in maximum membrane volumes of 20, 50, or 100 L, respectively. Pressure-flow performance and the shape of breakthrough curves are identical to the smaller capsule sizes, independent of the number of cassettes used. Set up can be accomplished within minutes, even at manufacturing scale.

Sartorius Stedim Biotech