Pharmaceutical Technology Editors

transcription (IVT) messenger RNA (mRNA) synthesis service is designed to offer a comprehensive solution for researchers seeking high-quality, customizable mRNA synthesis with fast turnaround times. The synthesis service is intended for use in molecular biology, drug discovery, vaccine development, and gene therapy, among other fields.

The IVT mRNA synthesis service is designed to handle various applications and includes customizable mRNA synthesis capabilities to meet specific research needs. Researchers can customize mRNA transcripts in various ways, including modifying the sequence, length, and purity of the mRNA.

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Eurofins Genomics Blue Heron IVT mRNA synthesis service is designed to provide researchers a customizable solution. 

Customizable mRNA Synthesis Service

Thermo Fisher Scientific’s Gibco OncePro Tumoroid Culture Medium Kit

Thermo Fisher Scientific’s Gibco OncePro Tumoroid Culture Medium Kit is a commercially available culture medium specifically developed for the expansion of patient-derived tumoroids, or cancer organoids, from multiple cancer indications.

As an off-the-shelf modular tumoroid culture medium kit, this product is designed to make it easier for cancer researchers to use patient-derived tumoroids to better model disease and predict patient response to therapeutics 

. In an effort to improve ease of use, the kit includes a scalable, automation-compatible suspension culture method.

In addition to the kit, Thermo Fisher Scientific offers Tumoroid Assay Development Services to support outsourced screening and characterization. Customers may also access seven unique OncoPro Tumoroid Cell Lines, representing four different cancer indications including colorectal, lung, endometrial, and breast.

Thermo Fisher Scientific’s Gibco OncePro Tumoroid Culture Medium Kit was specifically developed for the expansion of patient-derived tumoroids from multiple cancer indications. 

Tumoroid Culture Medium Kit

Ross Engineering custom fabricates tanks, pressure vessels, and reactors up to 100,000 gal or larger that are used throughout the processing industries for various manufacturing and storage functions.

The 9400-gal Condensate Receiver Tank is designed and built according to American Society Of Mechanical Engineers (ASME) standards for up to 5 psi at 200 °F. The tank is constructed from 304 stainless steel and includes multiple nozzles for venting, instrumentation, and discharge as well as a 24-in. American Petroleum Institute manway.

ROSS Engineering also offers hydrotesting, passivation, ASME code stamp, ladders, jacketing, insulation, agitators, and other customization.

Ross Engineering custom fabricates tanks, pressure vessels, and reactors for various manufacturing and storage functions. 

Custom-Fabricated Processing Tools

Bruker’s timsTOF Ultra mass spectrometer is designed for use with the company’s 4D-proteomics timsTOF platform. The device uses a new captive spray ionization ion source that provides a larger capillary relative to past models as well as optimized vortex gas flow.

The device is designed to identify over 55,000 peptides that map into 5000 protein groups at the single-cell level of 0.125 nanogram protein loading at less than 1% false discovery rate. More than 4800 protein groups are quantified at a coefficient of variation of less than 20%.

The parallel accumulation-serial fragmentation duty cycle can go as fast as 300 Hz for tandem mass spectrometry, which is intended to provide performance improvements for processes involving ultra-low sample amounts. This includes unbiased single-cell proteomics and single-cell lipidomics, unbiased spatial proteomics, immunopeptidomics, phosphoproteomics, post-translational modification analysis, and protein–protein interaction studies.

Bruker Corporations timsTOF Ultra mass spectrometer features a captive spray ionization ino sources that provides optimized vortex gas flow. 

Ultra-Low Sample Optimized Mass Spectrometer

TurboFil Packaging Machines’ Mini-Monoblock MDN-50

TurboFil Packaging Machines’ Mini-Monoblock MDN-50 fill/finish machine is designed to accurately and expediently fill, seal, cap, and label spray multi-dose nasal dispensers. The machine is suitable for vials with volumes from 4 to 30 mL and can process containers at a rate of up to 50 pieces per minute. It can be used with containers with tamp, crimp, and screw closures.

The machine uses a scroll conveyor designed to enable seamless vial loading while also allowing for a compact overall footprint. Vials are then transported to a starwheel ceramic piston filler station for clean and accurate filling; a second nozzle can be incorporated in the filler station for faster filling. Following this, the filled and sealed vials are conveyed to an optional wrap-around labeler with a thermal transfer printer that can apply lot code, manufacture/expiry dates, and other necessary information.

The Mini-Monoblock MDN-50 features a 7-in. touchscreen human–machine interface and escalating password levels for tiered personnel access. A three-color stack light with an audible alarm can alert personnel to potential issues, while ethernet capability allows for remote diagnostics.

TurboFil Packaging Machines Mini-Monoblock MDN-50 is designed to accurately and expediently fill, seal, cap, and label spray multi-dose nasal dispensers. 

Nasal Spray  Fill/Finish Machine

Beckman Coulter Life Sciences’ Light Array Module

The Light Array Module (LAM) from Beckman Coulter Life Sciences is designed to be used with the BioLector XT Microbioreactor, which faciliates the ability to work with light-dependent organisms requiring photosynthesis for growth. The device is intended for high-throughput screening and process optimization for various phototrophic organisms, including microalgae and cyanobacteria.

The module provides customizable light settings of 400–700 nanometers within the photosynthetic spectrum, including both day and night-time lighting. The device uses 16 different light-emitting diode (LED) types to achieve this degree of spectral flexibility; each LED can be controlled individually for maximum irradiances and photon flux densities of up to 3500 micromoles reaching one square meter per second.

The LAM uses real-time biomass, chlorophyll concentration, and fluorescence measures to provide real-time data without the need to pipette samples for analysis. The device is also capable of cultivation parameter monitoring and feeding strategy optimization.

Beckman Coulter Life Sciences’ Light Array Module enables high-throughput screening and process optimization for various phototrophic organisms. 