Pharmaceutical Technology Editors

The annual event covers supply chain, operations, facilities, and regulatory affairs, the role of data science including model-informed drug development (MIDD), and technology in shaping the future of product development, production systems, and quality assurance.

https://ispe.org/conferences/2024-annual-meeting-expo/register

Events

2024 ISPE Annual Meeting & Expo: Oct. 13-16, 2024

Salt Palace Convention Center, Salt Lake City, UT

 The event covers Discovery and Basic Research, Preclinical, Clinical and Translational Sciences, Bioanalytics, Manufacturing and Analytical Characterization, Formulation and Delivery, and Career Development.

AAPS 2024 PHARMSCI 360: October 20-23, 2024

ROSS Model HSM-405SC-25 Inline High Shear Mixer | Image Credit: © Charles Ross & Son Company

The ROSS Model HSM-405SC-25 Inline High Shear Mixer with solids/liquid injection manifold (SLIM) Technology is designed for production floors that require flexibility. The stainless-steel portable skid features a built-in workbench that helps save time and money. It allows the mixer to be used anywhere in a plant, eliminating the need for separate mixers for each vessel or product.

As an external mixer, the Inline SLIM can be piped to the recirculation loop of virtually any size vessel. Featuring sanitary tri-clamp connections, this 3A-compliant machine can be cleaned in place or quickly disassembled for deep cleaning and sanitation. Using the tabletop workbench, operators can open bags and load powders into the hopper that sits on top of the mixer, ensuring a consistent feed and minimizing aeration.

The SLIM is a unique rotor/stator device capable of injecting powders directly into a fast-moving liquid stream without the use of an eductor or pump. Engineered for high-speed and high-volume mixing requirements, this device can wet out powders and create a fine immediate dispersion, greatly reducing the occurrence of floating powders, lumps, and agglomerates.

Articles

The ROSS Model HSM-405SC-25 Inline High Shear Mixer features a built-in workbench and is designed for production floors that require flexibility.

Flexible Inline High Shear Mixer with Built-in Workbench

Thermo Scientific Heracell VIOS 250i AxD CO2 Incubators | Image Credit – © Thermo Fisher Scientific

Thermo Fisher Scientific has introduced the Thermo Scientific Heracell VIOS 250i AxD CO2 Incubators, first-of-their-kind CO2 incubators designed for integration into automated and modular laboratories to support future implementation of automated cell therapy workflows. The VIOS family of incubators are known for optimal cell growth conditions and minimal contamination risk. The new Heracell VIOS 250i AxD incubators have the added innovation of a patent-pending automated door control, allowing them to open automatically when integrated into a centralized lab automation platform. The added innovation allows for vessel loading and unloading through robotic control and supports continuous cell therapy production processes. Other important features include in-chamber high efficiency particulate air filtration; Thermo Scientific THRIVE active airflow for homogeneous culturing conditions throughout the incubator chamber; and the Thermo Scientific Steri-Run Cycle, which is capable of a 12-log sterility assurance level, eliminating more than one million biological indicators for both dry heat sterilization and autoclave sterilization in half the lethal time used in production models.

The VIOS family of incubators are known for optimal cell growth conditions and minimal contamination risk.

CO2 Incubators

ROSS Model VCB-20 | Image Credit: ©Charles Ross & Son Company

ROSS V Cone Blenders utilize diffusion as the main mechanism for mixing. As the V-shaped vessel rotates on its horizontal axis, batch materials cascade down, distributing particles over a freshly exposed surface. Operating at speeds of 5 to 25 revolutions per minute, the ROSS line of tumble blenders can mix dry solid blends (including high density powders), low-viscosity slurries, friable materials, and formulations containing trace components and ingredients that are dissimilar in size, shape, and density.

The pictured ROSS Model VCB-20 includes two pneumatic cylinders affixed to the V cone body to disconnect and connect fiber drums for charging and discharging. The blender’s butterfly valve is operated by optional pneumatic control. A high-speed intensifier bar is installed along the mixer’s axis of rotation to reduce agglomerates, and nozzles can be attached to it for continuous liquid additions during mixing. The model also includes carbon steel legs with 40” clearance beneath the discharge valve to the floor, and safety guardrails at the front and rear of the mixer.

Charles Ross & Son's ROSS V Cone Blenders utilize diffusion as the main mechanism for mixing.

V-Shaped Cone Tumble Blender

Deitz’s Pharmafill TC4 tabletop tablet counter includes an automatic feeder control system to ensure a consistent volume of tablets is fed onto a rotating disc for feeding to the counting sensor. The automatic feeding system features a proximity sensor assembly that automatically stops the flow of tablets from the hopper if the flow rate exceeds the pace of the operator filling the bottles. When ready for additional tablets, the system automatically restarts the vibratory feeder and restores product flow at the preset rate.

The TC4 is suitable for counting and filling capsules, gelcaps, pills, softgels, and other opaque, translucent, and transparent oral solid dosage forms. The compact electronic tablet counter achieves filling rates of up to 2000 tablets per minute, filling bottles up to 10 inches in height. The semi-automated pill counting machine comes with a two-year warranty and arrives ready to plug in to common 110 VAC electrical services.

Deitz’s Pharmafill TC4 tabletop tablet counter is suitable for counting and filling capsules, gelcaps, pills, softgels, and other opaque, translucent, and transparent oral solid dosage forms.