Pharmaceutical Technology Editors

Syngene International, a contract research, development, and manufacturing organization (CRDMO), now offers a new protein production platform aimed at rapid protein synthesis. The platform uses a cell line and transposon-based technology that Syngene licensed from ExcellGene, a Switzerland-based service provider specializing in mammalian cell line development. 

Editor’s note: this article was published in the Aug. 1, 2024 issue of 

The new protein synthesis platform, combined with Syngene’s clone selection and development processes, offers significant improvement in efficiency and precision. The platform offers faster preclinical and clinical development and shorter timelines to product launches, shortening time to market. Advantages include up to 10 weeks reduction in time versus traditional cell line development methods; better predictability and protein yields, with high-titer levels of up to 10 g/L achieved; support for a variety of modalities, including monoclonal antibodies, biosimilars, bispecific antibodies, antibody drug conjugates, and other recombinant proteins. In addition, the platform’s versatility facilitates integration with perfusion and fed-batch manufacturing processes.

Articles

Syngene’s protein production platform uses a cell line and transposon-based technology licensed from Switzerland-based ExcellGene.

New Protein Production Platform

Thermo’s DNAPac RP HPLC columns | Image Credit: Thermo Fisher Scientific

The Thermo Scientific SurePac Bio 550 SEC MDi columns enable fast separations of adeno-associated virus (AAV) monomers and aggregates. The columns are designed with 3 µm monodisperse particles and inert (MDi) column hardware aimed at providing superior AAV monomer retention and higher resolution of aggregates in cell and gene therapies. 

These columns offer fast run times, optimal separation efficiency, and reliable results with the goal of accelerating time-to-market for novel therapeutics. In addition, Thermo’s DNAPac RP HPLC columns (pictured here) are offered in semi-preparative formats to enable scalability in the development of DNA/RNA oligonucleotides. The DNAPac RP semi-preparative columns are designed so that laboratories can navigate the expanding field of oligonucleotide therapies and precision medicine. The DNAPac RP semi-preparative column utilizes unique chemistry for enhanced performance across wide ranges of pH, temperature, and mobile-phase compositions, offering precise separations and sample purification.

These columns offer fast run times, optimal separation efficiency, and reliable results.

Separation and Purification Columns

Westin Washington, DC Downtown, Washington, DC

 The co-sponsored event includes sessions, interactive discussions, regulatory updates, and case studies regarding the current good manufacturing practice requirements.

https://www.pda.org/global-event-calendar/conferences/pda-fda-joint-regulatory-conference-2024

Events

The co-sponsored event includes sessions, interactive discussions, regulatory updates, and case studies regarding the current good manufacturing practice requirements.

PDA/FDA Joint Regulatory Conference 2024: Sept. 9–11, 2024

The event will explore new technologies such as AI, digital twins, development approaches, CMC strategies, and regulatory frameworks, supporting rapid access to vaccines and biotherapeutics. 

https://www.pda.org/global-event-calendar/event-detail/pda-biomanufacturing-conference-2024#registration

The event will explore new technologies such as AI, digital twins, development approaches, CMC strategies, and regulatory frameworks, supporting rapid access to vaccines and biotherapeutics. 



 PDA BioManufacturing Conference 2024: Sept. 24 and 25, 2024

This event will feature a look at the crucial nexus between scientific advancement and regulatory adherence.

https://www.pda.org/global-event-calendar/conferences/pda-pharmaceutical-microbiology-conference-2024

PDA Pharmaceutical Microbiology Conference 2024: Oct 7–9, 2024

 CPHI Milan connects thought leaders and innovators in the pharma industry.


https://www.cphi.com/europe/en/registration.html

CPHI Milan connects thought leaders and innovators in the pharma industry.