Drug Development

Articles

The authors describe a novel analytical approach that uses the shape-analysis capabilities of MFI to detect and enumerate silicone oil microdroplets in protein formulations that also contain aggregates of similar size and in a similar concentration.

Silicone Microdroplets in Protein Formulations—Detection and Enumeration

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

A review of recent product innovations, policy developments, and growth prospects in the excipients market.

Tracking Excipients

The spotlight on the biopharmaceutical industry is intensifying, as recently evidenced by Pfizer's (New York) ongoing acquisition of Wyeth (Madison, NJ), which was initiated partly to reduce the former's dependence on small-molecule drugs.

The Shape of Biopharmaceutical Facilities to Come

Ultra high performance liquid chromatography is advantageous in a contract laboratory because it is faster, more sensitive, and relies on smaller volumes of organic solvents than HPLC.

Ultra High Performance Liquid Chromatography in the Contract Manufacturing Environment

Contract manufacturers deploy a business model using operations in the US and Western Europe with facilities in Asia.

Narrowing the Geographic Divide in API Sourcing

Without any GMP guidelines for excipients in Europe, change can't come soon enough for some industry groups.

Inside IPEC: Regulation for Excipients is Brewing Across the Atlantic

The pharmaceutical majors forward projects in biocatalysis, solvent replacement, and other approaches in green chemistry.

Going Green in Pharmaceuticals

Michigan State University researchers have discovered a technique for viewing whole cells to gain an understanding of protein inclusion bodies.

NMR Approach May Speed Up Protein-Based Drug Development

Catalysis for olefin metathesis and aldol reactions and synthetic routes to natural products are some recent gains.

APIs and Excipients