Drug Development

Articles

Michigan State University researchers have discovered a technique for viewing whole cells to gain an understanding of protein inclusion bodies.

NMR Approach May Speed Up Protein-Based Drug Development

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Catalysis for olefin metathesis and aldol reactions and synthetic routes to natural products are some recent gains.

Optimizing Small-Molecule Synthesis

The authors describe a novel analytical approach that uses the shape-analysis capabilities of MFI to detect and enumerate silicone oil microdroplets in protein formulations that also contain aggregates of similar size and in a similar concentration.

Silicone Microdroplets in Protein Formulations—Detection and Enumeration

A recent Pharmaceutical Technology survey examined the level, sources, and reasons behind innovation in drug development and manufacturing. This article contains bonus online-exclusive material.

Gauging Innovation in Pharmaceutical Development and Manufacturing

Sanjay Garg, PhD, is an associate professor at the School of Pharmacy, University of Auckland, Auckland, New Zealand, and a member of the Pharmaceutical Technology Editorial Advisory Board.

A book about pharmaceutical analysis engages the reader with history and unexpected asides.

A Peak in Mass-Spectrometry Literature

Optimizing the solid form of a drug reaps scientific and technical awards.

Exploring Solid-State Chemistry

Theodore H. Meltzer is principle of Capitola Consultancy.

A well-balanced guide to industrial bioseparations provides valuable information.

Bringing Certainties to a Burgeoning Field

S. Gebert is a pharmaceutical engineer, BASF

K. Meyer-Böhm is a research and development (R&D) manager, BASF

K. Kolter, PhD, is head of R&D for pharmaceutical excipients, BASF SE, G-EMP-MD-H201, Ludwigshafen, Germany, 67056, tel. + 49 621 6041664, fax; 49 621 6097370, karl.kolter@basf.com

The authors examine the effectiveness of an excipient comprised of mannitol, polyvinyl acetate, and crospovidone using model actives loperamide hydrogen chloride and caffeine.

Development of Orally Disintegrating Tablets Based on a New Excipient

Sophisticated excipient development, especially for coatings, is staying on top of new challenges and meeting expanding industry needs.

A Fresh Coat: Innovation in Excipients

IPEC Chairman Dave Schoneker discusses current efforts toward facilitating regulatory reviews of new excipients.

APIs and Excipients