Drug Development

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Articles

Understanding the API, delivery mechanism, and excipient functionality is essential to solving drug solubility challenges.


Strategic Screening for Solubility Solutions

Felicity Thomas is the former Associate Editorial Director of Pharmaceutical Technology, Pharmaceutical Technology Europe, BioPharm International.

As biologics continue to push boundaries, the industry needs to take a holistic approach to formulation to ensure success.

Rising to the Challenge of Biologic Drug Formulation

Mustang intends to combine an oncolytic virus with an interleukin-13 Rα2-(IL13Rα2)-specific chimeric antigen receptor to potentially enhance efficacy in treating glioblastoma multiforme.

Mustang Bio, Nationwide Children’s Hospital Sign License Agreement for Oncolytic Virus Therapy

In a deal worth $530 million, the companies will develop and commercialize an anti-epileptic drug candidate in Europe.

SK Biopharmaceuticals, Arvelle Partner on Anti-Epileptic Drug for Europe

The partners will collaborate on the development and commercialization of a B-cell maturation antigen-targeting immunotherapeutic for treating multiple myeloma.

AbbVie, Teneobio Partner on Multiple Myeloma Treatment

The multi-year agreement will give Novartis access to AbCellera’s expertise and state-of-the-art antibody discovery technology for up to ten clinically-relevant disease targets.

Novartis, AbCellera in Antibody Discovery Pact

A solid lipid excipient from ABITEC is designed for multiple dosing forms.

Lipid Excipient Targets Multiple Dose Forms

Kieran O’Connor is Analytical Science and Technology senior chemist at SK biotek, Ireland, kieran.oconnor@sk.com. (formerly Bristol Myers Squibb)

John Wasylyk is senior principal scientist at Bristol-Myers Squibb, USA; john.wasylyk@bms.com

Bob Wethman is senior research scientist II at Bristol-Myers Squibb, USA

Ming Huang is senior research investigator I at Bristol-Myers Squibb, USA

Spectroscopic-based control methods were introduced as equivalent alternative methods, first to a gas chromatographic method to monitor an in-process solvent exchange step and second to a potentiometric titration method to release a process input material for drug substance manufacturing. 

Spectroscopy Facilitates Lean Analysis

New platform technologies, advanced modeling tools, and addressing patient needs are important developments.

Advances in Engineering of Protein-Based APIs

Janssen and MeiraGTx will collaborate on the development and commercialization of gene therapies for treating inherited retinal diseases.

APIs and Excipients