Drug Development

Articles

The agency issued its recommendation for the influenza virus strains European vaccine manufacturers should include for 2017.

EMA Updates Flu Vaccination Recommendations

In a new study, researchers from Boston Children’s Hospital study responses to pneumococcal vaccine in infant monkeys.

Researchers Study Vaccine Responses in Newborns

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Researchers continue efforts to overcome challenges of effective oral delivery of biologic drugs.

Seeking Solutions for Oral Delivery of Biologic APIs

Carglumic acid is used in the management of rare, life-threatening inborn metabolic disorders affecting the urea cycle.

Dipharma Strengthens Pipeline with Stable, Fast-Dissolving Carglumic Acid Tablets

Vicky Qing XIA is Project Director at BioPlan Associates.

New study shows China biopharma companies face staffing shortages.

Staffing for China’s Rapidly Growing Biomanufacturing Industry

The transfer of fluids is governed by different equipment requirements across the medical, biopharma, and cell therapy manufacturing industries.

Enabling Fluid Transfer for Cell Therapies: An Industry Challenge

Jennifer Markarian is a contributing editor for 

The process control and automation requirements of single-use systems differ from those of stainless-steel equipment.

Automating Bioprocesses

Adeline Siew is editor for Pharmaceutical Technology Europe. She is also science editor for Pharmaceutical Technology.

Design of experiment plays a crucial role in the optimization process of formulation development.

Designing Optimized Formulations

Simon Gaisford is professor of pharmaceutics at UCL School of Pharmacy, University College London, 29â39 Brunswick Square, London, WC1N 1AX, United Kingdom, and director at Wattsense Ltd, 3 Romney Road, Ashford, Kent, TN24 0RW, United Kingdom; Tel: +44 (0) 20 7753 5863, Fax: +44 (0) 20 7753 5942, s.gaisford@ucl.ac.uk.

Interpretation of calorimetric data is tricky. The author suggests 10 questions that should be asked of any calorimetric method, along with the rationales behind them.

Considerations when Quantifying Amorphous Contents in Milled Powders with Calorimetry

Stephen Moller is application scientist, Evonik Corporation, 2 Turner Place, Piscataway, NJ 08855, US, Tel.: +1 732 981 5110, stephen.moller@evonik.com.

JÃ¶rg MuÌnzenberg, PhD, is senior manager, Applied Technology, Evonik Resource Efficiency GmbH, Rodenbacher Chaussee 4, 634567 Hanau, Germany, Tel.: +49 6181 59 2217, joerg.muenzenberg@evonik.com

Solid dispersions based on organic polymers can have stability issues. Inorganic solids, especially those based on silica chemistry, may be suitable alternatives to organic polymers due to their pre-formed pore system, high absorptivity, and commercial availability in pharmaceutical quality. Mesoporous granulated colloidal silicon dioxide has been studied with class II and IV actives of the Biopharmaceutics Classification System for its ability to improve dissolution. Using suitable formulation strategies, the dissolution of these APIs could be significantly increased. The absorption of poorly soluble APIs onto silicon dioxide can, therefore, be considered a viable formulation path to overcome solubility challenges.

Formulation and Drug Delivery