Drug Development

Patricia Van Arnum was executive editor of Pharmaceutical Technology.

Articles

The pharmaceutical majors deploy green-chemistry strategies to improve the synthesis of active pharmaceutical ingredients and intermediates.

Advances in Green Chemistry for Pharmaceutical Applications

Ram Murty is the president of Murty Pharmaceuticals and a member of Pharmaceutical Technology's Editorial Advisory Board.

A recent book shows the links between synthesis, catalysis, and environmental protection.

A Catalyst for Environmental Consciousness

This year, the employment survey will acknowledge the industry's best employers.

Make Yourself Count

Carbon–hydrogen functionalization, ketone α-alkylation, and biocatalysis are some recent advances in asymmetric synthesis.

Achieving Enantioselectivity

Michelle Hoffman, editorial director of Pharmaceutical Technology.

Are hypersanitation trends a result of scaremongering or a lack of faith in medicine?

Dirty Hands

The author explains the planning, equipment, and facility design requried for manufacturing HPAPIs and specialized requirements for handling these compounds.

High-Potency APIs: Containment and Handling Issues

The outlook is fairly optimistic as contract manufacturing organizations (CMOs) gather at CPhI Worldwide in Frankfurt. CMOs are expanding capacity for small-molecules, biologics, and finished-product manufacturing.

Expansion Activity of CMOs

Near-infrared spectroscopy (NIR) is suitable for the analysis of pharmaceutical samples in various solid forms, and can be used for determining chemical properties (e.g., content of drug, water), as well as physical properties (e.g., particle size, tablet hardness).

Pseudo-polymorphic conversion by near-infrared spectroscopy

EPedigree, track-and-trace technologies, and other tools for optimizing supply-chain management are of increasing importance to the pharmaceutical industry. The author examines the current regulatory and legislative framework for ePedigree for finished drug products as well as proposals to require electronic statements for pharmaceutical ingredients.

Epedigree in the Pharmaceutical Supply Chain

Recombinant microbial whole-cell biocatalysis is a valuable approach for producing enantiomerically pure intermediates. The authors examine several groups of enzymes using this approach: dehydrogenases, hydantoinases, and acylases.

Ingredients